Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004087-10
Application #
2153551
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1986-06-15
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rutgers University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Caffrey, P B; Frenkel, G D (2000) Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo. Cancer Chemother Pharmacol 46:74-8
Caffrey, P B; Zhu, M; Zhang, Y et al. (1999) Rapid development of glutathione-S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid. Cancer Lett 136:47-52
Caffrey, P B; Zhang, Y; Frenkel, G D (1998) Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in Vivo. Anticancer Res 18:3021-5
Zhu, M; Gong, Y; Frenkel, G D (1998) Studies on the mechanism of the selenite-induced decrease in cell attachment: effect of selenite on the levels of fibronectin receptor (alpha5beta1 integrin) mRNAs. Biol Trace Elem Res 62:123-34
Caffrey, P B; Frenkel, G D (1998) Treatment of human ovarian tumor xenografts with selenite prevents the melphalan-induced development of drug resistance. Anticancer Res 18:3017-20
Caffrey, P B; Zhu, M; Frenkel, G D (1998) Prevention of the development of melphalan resistance in vitro by selenite. Biol Trace Elem Res 65:187-95
Caffrey, P B; Frenkel, G D (1997) Sensitivity of melphalan-resistant tumors to selenite in vivo. Cancer Lett 121:177-80
Yan, L; Frenkel, G D (1994) Protein synthesis is not required for the inhibitory effect of selenite on cell colony formation and RNA synthesis. Biol Trace Elem Res 40:181-7
Yan, L; Frenkel, G D (1994) Effect of selenite on cell surface fibronectin receptor. Biol Trace Elem Res 46:79-89
Caffrey, P B; Frenkel, G D (1994) The development of drug resistance by tumor cells in vitro is accompanied by the development of sensitivity to selenite. Cancer Lett 81:59-65

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