Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES009158-04
Application #
6178447
Study Section
Special Emphasis Panel (ZRG4-HPD (06))
Program Officer
Mastin, Patrick
Project Start
1997-06-01
Project End
2001-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
4
Fiscal Year
2000
Total Cost
$113,432
Indirect Cost
Name
Louisiana State University Hsc Shreveport
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Shreveport
State
LA
Country
United States
Zip Code
71103
Tan, Wei; Pruett, Stephen B (2015) Effects of sodium methyldithiocarbamate on selected parameters of innate immunity and clearance of bacteria in a mouse model of sepsis. Life Sci 139:1-7
Pruett, Stephen B; Fan, Ruping; Zheng, Qiang et al. (2009) Patterns of immunotoxicity associated with chronic as compared with acute exposure to chemical or physical stressors and their relevance with regard to the role of stress and with regard to immunotoxicity testing. Toxicol Sci 109:265-75
Pruett, Stephen B; Fan, Ruping; Zheng, Qiang (2006) Involvement of three mechanisms in the alteration of cytokine responses by sodium methyldithiocarbamate. Toxicol Appl Pharmacol 213:172-8
Dai, Qun; Zhang, Jun; Pruett, Stephen B (2005) Ethanol alters cellular activation and CD14 partitioning in lipid rafts. Biochem Biophys Res Commun 332:37-42
Pruett, Stephen B; Zheng, Qiang; Schwab, Carlton et al. (2005) Sodium methyldithiocarbamate inhibits MAP kinase activation through toll-like receptor 4, alters cytokine production by mouse peritoneal macrophages, and suppresses innate immunity. Toxicol Sci 87:75-85
Pruett, Stephen B; Padgett, Eric L (2004) Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse. BMC Immunol 5:24
Pruett, Stephen B; Fan, Ruping; Zheng, Qiang et al. (2003) Modeling and predicting immunological effects of chemical stressors: characterization of a quantitative biomarker for immunological changes caused by atrazine and ethanol. Toxicol Sci 75:343-54
Hebert, P; Pruett, S B (2001) Selective loss of viability of mouse NK cells in culture is associated with decreased NK cell lytic function. In Vitr Mol Toxicol 14:71-82
Myers, L P; Krieg, A M; Pruett, S B (2001) Bacterial DNA does not increase serum corticosterone concentration or prevent increases induced by other stimuli. Int Immunopharmacol 1:1605-14
Pruett, S B; Fan, R (2001) Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress. J Toxicol Environ Health A 62:175-89

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