Chronic obstructive pulmonary disease (COPD) is a common disease that results in considerable morbidity and mortality. Epidemiological studies indicate that persons with COPD are particularly susceptible to the effects of traffic related particles. To date, our knowledge regarding these effects is mostly derived from community-based epidemiologic studies using administrative databases and population exposures. Epidemiological observations indicating effects in large population samples have not yet been demonstrated in patients with COPD and the mechanisms of disease remain uncertain. Previous efforts to study the health effects of air pollution in patients with COPD have been limited by inadequate sample size, an inadequate assessment of personal exposure, and lack of a suitable cohort. We have addressed these limitations and will study the effects of traffic-related pollution in 300 persons with moderate to severe COPD recruited from patients receiving clinical care at VA Boston. We hypothesize that when assessed over one year, exposure to traffic-related particles as measured by black carbon will result in exacerbations of COPD, a reduction in pulmonary function, an increase in measures of systemic inflammation, and an increase in systemic oxidative stress in a dose-related manner. Exposure will be assessed by a Boston-area black carbon spatio-temporal land use regression model with model validation by in-home monitoring The information obtained from this research project will define the exposure response relationships between traffic-related particles and the clinical, pulmonary, and systemic responses to air pollution in patients with COPD.

Public Health Relevance

COPD is a common disease that results in considerable morbidity and mortality. Epidemiologic studies have identified these patients as a group susceptible to the adverse effects of traffic related air pollution. We will examine the dose response relationship between traffic related air pollution exposures with exacerbations, change in pulmonary function, and systemic response in patients with COPD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES019853-02
Application #
8481548
Study Section
Special Emphasis Panel (ZRG1-PSE-K (02))
Program Officer
Dilworth, Caroline H
Project Start
2012-06-05
Project End
2017-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
2
Fiscal Year
2013
Total Cost
$591,218
Indirect Cost
$113,215
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
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Blomberg, Annelise J; Coull, Brent A; Jhun, Iny et al. (2018) Effect modification of ambient particle mortality by radon: a time series analysis in 108 U.S. cities. J Air Waste Manag Assoc :
Garshick, Eric; Grady, Stephanie T; Hart, Jaime E et al. (2018) Indoor black carbon and biomarkers of systemic inflammation and endothelial activation in COPD patients. Environ Res 165:358-364
Grady, Stephanie T; Koutrakis, Petros; Hart, Jaime E et al. (2018) Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease. Environ Int 115:188-195
Nyhan, Marguerite M; Coull, Brent A; Blomberg, Annelise J et al. (2018) Associations Between Ambient Particle Radioactivity and Blood Pressure: The NAS (Normative Aging Study). J Am Heart Assoc 7:
Rokoff, Lisa B; Koutrakis, Petros; Garshick, Eric et al. (2017) Wood Stove Pollution in the Developed World: A Case to Raise Awareness Among Pediatricians. Curr Probl Pediatr Adolesc Health Care 47:123-141
Garshick, Eric (2014) Effects of short- and long-term exposures to ambient air pollution on COPD. Eur Respir J 44:558-61