Abstract

The pathogenesis and treatment of retinal vascular lesions of diabetes are to be investigated in dogs, a species known to develop microvascular lesions indistinguishable from those seen in diabetes mellitus in patients. The evolution of retinopathy is to be studied ophthalmoscopically and histologically in diabetic dogs, and in a new model of diabetic reginopathy discovered in experimentally galactosemic dogs. Diabetic animals and galactosemic animals are to be compared with respect to changes occurring in tissue morphology, biochemistry and physiology to identify abnormalities associated with and possibly responsible for the retinopathy. The potential role of excessive polyol production in the pathogenesis of diabetic retinopathy is being examined, and effects of administration of an aldose reductase inhibitor on the development of retinal and related complications are being investigated in the diabetic dog and galactosemic dog models. Metabolic activity of isolated retinal microvessels is to be documented and compared with that of cerebral microvessels. The extent to which early retinopathy can be arrested or reversed by correction of hyperglycemia is to be evaluated in galactosemic dogs for comparison with similar studies by us currently in diabetic dogs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY000300-26
Application #
3255236
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1977-12-01
Project End
1996-02-29
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
26
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Flückiger, Rudolf; Cocuzzi, Enzo; Nagaraj, Ram H et al. (2018) DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol Immunol 93:246-252
Nahomi, Rooban B; Sampathkumar, Sruthi; Myers, Angela M et al. (2018) The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci 59:2042-2053
Tonade, Deoye; Liu, Haitao; Palczewski, Krzysztof et al. (2017) Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia 60:2111-2120
Kern, Timothy S (2017) Do photoreceptor cells cause the development of retinal vascular disease? Vision Res 139:65-71
Tonade, Deoye; Kern, Timothy S (2017) Diabetes of 5 years duration does not lead to photoreceptor degeneration in the canine non-tapetal inferior-nasal retina. Exp Eye Res 162:126-128
Tonade, Deoye; Liu, Haitao; Kern, Timothy S (2016) Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes. Invest Ophthalmol Vis Sci 57:4264-71
Zhang, Lingjun; Li, Yan; Payne, John et al. (2016) Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients. Sci Rep 6:20341
Liu, Haitao; Tang, Jie; Du, Yunpeng et al. (2016) Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci 57:4272-81
Liu, Haitao; Tang, Jie; Du, Yunpeng et al. (2015) Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem 290:21568-79
Saliba, Alexandra; Du, Yunpeng; Liu, Haitao et al. (2015) Photobiomodulation Mitigates Diabetes-Induced Retinopathy by Direct and Indirect Mechanisms: Evidence from Intervention Studies in Pigmented Mice. PLoS One 10:e0139003

Showing the most recent 10 out of 95 publications