Diabetic retinopathy, the retinal vascular disease secondary to diabetes, is a leading cause of adult blindness. Today, treatment is relatively successfully aimed retarding the progress and limiting the severe stages of proliferative retinopathy, which is associated with high risk for blindness. With success of these treatments, attention is moving to therapies (e.g., aspirin, aldose reductase inhibitors, tight diabetic control) which might eliminate or reduce the onset of even the mildest forms of retinopathy. Unfortunately, the traditional vision function tests which might be used to monitor the efficacy of any of these treatments often don't show any abnormal vision changes, even after the development of substantial retinopathy. Our laboratory psychophsical tests of vision, particularly of B cone function, show that visual function is often altered prior to development of retinopathy and can be measured easily with clinically viable instrumentation. Further, the earliest sensitivity changes may have a post-receptoral origin and fluctuate with diabetic control.
The specific aims of this study are: 1) to relate acute and sustained diabetic blood glucose control in B cone sensitivity measures, 2) establish clear-cut evidence for post-receptoral involvement, as an early sign, with tests which can be adapted to testing clinical patients, 3) correlate local non-foveal retinopathic signs (e.g., capillary non-perfusion) to B cone sensitivity, and 4) use clinical instrumentation measures (BCT) of B cone sensitivity to monitor effects of treatment and change in retinopathic grade in individual diabetics.
Ozawa, Glen Y; Bearse Jr, Marcus A; Adams, Anthony J (2015) Male-female differences in diabetic retinopathy? Curr Eye Res 40:234-46 |
Wolff, B E; Bearse Jr, M A; Schneck, M E et al. (2015) Color vision and neuroretinal function in diabetes. Doc Ophthalmol 130:131-9 |
Dhamdhere, Kavita P; Schneck, Marilyn E; Bearse Jr, Marcus A et al. (2014) Assessment of macular function using the SKILL Card in adults with type 2 diabetes mellitus. Invest Ophthalmol Vis Sci 55:3368-74 |
Ozawa, Glen Y; Bearse Jr, Marcus A; Harrison, Wendy W et al. (2014) Differences in neuroretinal function between adult males and females. Optom Vis Sci 91:602-7 |
Adams, Anthony J; Bearse Jr, Marcus A (2012) Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention? Clin Exp Optom 95:256-65 |
Tam, Johnny; Dhamdhere, Kavita P; Tiruveedhula, Pavan et al. (2012) Subclinical capillary changes in non-proliferative diabetic retinopathy. Optom Vis Sci 89:E692-703 |
Ozawa, Glen Y; Bearse Jr, Marcus A; Bronson-Castain, Kevin W et al. (2012) Neurodegenerative differences in the retinas of male and female patients with type 2 diabetes. Invest Ophthalmol Vis Sci 53:3040-6 |
Harrison, Wendy W; Chang, Ann; Cardenas, Maria G et al. (2012) Blood pressure, vessel caliber, and retinal thickness in diabetes. Optom Vis Sci 89:1715-20 |
Laron, Michal; Bearse Jr, Marcus A; Bronson-Castain, Kevin et al. (2012) Association between local neuroretinal function and control of adolescent type 1 diabetes. Invest Ophthalmol Vis Sci 53:7071-6 |
Laron, Michal; Bearse Jr, Marcus A; Bronson-Castain, Kevin et al. (2012) Interocular symmetry of abnormal multifocal electroretinograms in adolescents with diabetes and no retinopathy. Invest Ophthalmol Vis Sci 53:316-21 |
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