The main objective with this project is to learn more about the role of genetic and environmental factors in the development of the central nervous system. The request is for a continuation of our studies of the visual system in normal and visually deprived monkeys and cats. Receptive field analysis of single cells will continue to be our main technique in these studies but other methods are certain to be used more and more to complement the physiology. The new anatomical techniques developed during the last few years have already proven their usefulness and we foresee new developments in this area. Behavioral studies will continue to be used to raise monkeys under various conditions of visual deprivation. The neurochemical work on the vertebrate retina will be continued; this approach is not yet fully integrated with our studies of the mammalian visual system but we intend to adapt the methods developed for studies of normal and visually deprived animals.
| Luo-Li, Gloria; Mazade, Reece; Zaidi, Qasim et al. (2018) Motion changes response balance between ON and OFF visual pathways. Commun Biol 1:60 |
| Kremkow, Jens; Alonso, Jose-Manuel (2018) Thalamocortical Circuits and Functional Architecture. Annu Rev Vis Sci 4:263-285 |
| Alonso, Jose Manuel (2018) Motion processing picks up speed in the brain. Nature 558:38-39 |
| Pons, Carmen; Mazade, Reece; Jin, Jianzhong et al. (2017) Neuronal mechanisms underlying differences in spatial resolution between darks and lights in human vision. J Vis 17:5 |
| Mazade, Reece; Alonso, Jose Manuel (2017) Thalamocortical processing in vision. Vis Neurosci 34:E007 |
| Koch, Erin; Jin, Jianzhong; Alonso, Jose M et al. (2016) Functional implications of orientation maps in primary visual cortex. Nat Commun 7:13529 |
| Kremkow, Jens; Perrinet, Laurent U; Monier, Cyril et al. (2016) Push-Pull Receptive Field Organization and Synaptic Depression: Mechanisms for Reliably Encoding Naturalistic Stimuli in V1. Front Neural Circuits 10:37 |
| Kremkow, Jens; Jin, Jianzhong; Wang, Yushi et al. (2016) Principles underlying sensory map topography in primary visual cortex. Nature 533:52-7 |
| Wool, Lauren E; Komban, Stanley J; Kremkow, Jens et al. (2015) Salience of unique hues and implications for color theory. J Vis 15: |
| Zhao, Linxi; Sendek, Caroline; Davoodnia, Vandad et al. (2015) Effect of Age and Glaucoma on the Detection of Darks and Lights. Invest Ophthalmol Vis Sci 56:7000-6 |
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