Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY005856-10S1
Application #
2159615
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-07-16
Project End
1995-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Washington University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Zukin, Leonid M; Pedler, Michelle G; Groman-Lupa, Sergio et al. (2018) Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery. Invest Ophthalmol Vis Sci 59:3591-3598
Zhang, Chi; Lai, Maria B; Pedler, Michelle G et al. (2018) Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature. Arterioscler Thromb Vasc Biol 38:2691-2705
Chang, Kun-Che; Shieh, Biehuoy; Petrash, J Mark (2017) Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chem Biol Interact 276:149-154
Chang, Kun-Che; Shieh, Biehuoy; Petrash, J Mark (2016) Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun 473:565-71
Chang, Kun-Che; Li, Linfeng; Sanborn, Theresa M et al. (2016) Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. J Nat Prod 79:1439-44
Diego, Jose L; Bidikov, Luke; Pedler, Michelle G et al. (2016) Effect of human milk as a treatment for dry eye syndrome in a mouse model. Mol Vis 22:1095-1102
Nagaraj, Ram H; Nahomi, Rooban B; Mueller, Niklaus H et al. (2016) Therapeutic potential of ?-crystallin. Biochim Biophys Acta 1860:252-7
Chang, Kun-Che; Petrash, J Mark (2015) Aldose Reductase Mediates Transforming Growth Factor ?2 (TGF-?2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Invest Ophthalmol Vis Sci 56:4198-210
Snow, Anson; Shieh, Biehuoy; Chang, Kun-Che et al. (2015) Aldose reductase expression as a risk factor for cataract. Chem Biol Interact 234:247-53
Chang, Kun-Che; Snow, Anson; LaBarbera, Daniel V et al. (2015) Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact 234:254-60

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