Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY006431-13
Application #
2160196
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1989-02-01
Project End
1999-11-30
Budget Start
1995-12-06
Budget End
1996-11-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Doheny Eye Institute
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Lee, Jeong Goo; Kay, EunDuck P (2012) NF-?B is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea. Invest Ophthalmol Vis Sci 53:1530-8
Lee, Jeong Goo; Song, Jong-Suk; Smith, Ronald E et al. (2011) Human corneal endothelial cells employ phosphorylation of p27(Kip1) at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase. Invest Ophthalmol Vis Sci 52:8216-23
Lee, Jeong Goo; Kay, EunDuck P (2011) PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2. Invest Ophthalmol Vis Sci 52:417-26
Song, Jong-Suk; Lee, Jeong Goo; Kay, EunDuck P (2010) Induction of FGF-2 synthesis by IL-1beta in aqueous humor through P13-kinase and p38 in rabbit corneal endothelium. Invest Ophthalmol Vis Sci 51:822-9
Lee, Jeong Goo; Kay, EunDuck P (2009) Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1beta in corneal endothelial cells. Invest Ophthalmol Vis Sci 50:2067-76
Lee, Jeong Goo; Kay, EunDuck P (2008) Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells. Invest Ophthalmol Vis Sci 49:189-96
Kay, E P; Gu, X; Smith, R E (1994) Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer. Invest Ophthalmol Vis Sci 35:2427-35
Kay, E P; Gu, X; Ninomiya, Y et al. (1993) Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that modulates cell shape and collagen. Invest Ophthalmol Vis Sci 34:663-72
Kay, E P; He, Y G (1991) Post-transcriptional and transcriptional control of collagen gene expression in normal and modulated rabbit corneal endothelial cells. Invest Ophthalmol Vis Sci 32:1821-7
Kay, E P; Rivela, L; He, Y G (1990) Corneal endothelium modulation factor released by polymorphonuclear leukocytes. Partial purification and initial characterization. Invest Ophthalmol Vis Sci 31:313-22

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