The objective of the proposed research remains to learn more about human ocular motor disorders that impair vision, and to appraise therapeutic measures. The research strategy is to (1) study natural behaviors such as combined eye-head tracking; (2) relate reliable measurements of eye movements to visual complaints of patients; (3) interpret the control of normal and abnormal eye movements using mathematical models that are based on known physiologic properties. In this way we plan to apply new knowledge of pathogenesis to the diagnosis and treatment of disorders of ocular motility. This proposal has five aims that emerge from prior work. One is to evaluate the role of botulinum toxin injections into selected extraocular muscles as a treatment for impaired vision and oscillopsia due to acquired nystagmus. By selecting patients in whom stabilization of retinal images by electronic means improves vision, it should be possible to produce appreciable, if temporary, improvement of symptoms. Two further projects concern study of torsional eye movements, relating them to the visual demands that they serve. We will focus on normal visuo-vestibular interaction, and investigate the mechanisms that account for suppression of vestibular eye movements when subjects view a display that moves in the roll plane with their heads. We will also study torsional eye movements in patients with disorders of vertical or horizontal gaze, to identify the involvement of the torsional system.
The aim of a fourth project is to compare dynamic properties of ocular smooth-pursuit eye movements with those of combined eye-head tracking, the latter being the more natural way to visually track a moving object.
The aim of the fifth project is to determine how discrete, unilateral lesions of cerebral cortex impair combined eye-head tracking, compared with purely ocular smooth pursuit. These projects will provide (1) an evaluation of a new treatment method for visual symptoms due to acquired nystagmus; (2) new information on the role of torsional eye movements and the deficits produced by disease; (3) new insights into how natural, combined, eye-head tracking allows a clear view of a moving object, and how such tracking is affected by lesions affecting secondary visual areas in cerebral cortex.
| Shaikh, Aasef G; Ghasia, Fatema F (2017) Novel Eye Movement Disorders in Whipple's Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia. Front Neurol 8:321 |
| Shaikh, Aasef G; Ghasia, Fatema F (2017) Fixational saccades are more disconjugate in adults than in children. PLoS One 12:e0175295 |
| Ghasia, Fatema F; Wilmot, George; Ahmed, Anwar et al. (2016) Strabismus and Micro-Opsoclonus in Machado-Joseph Disease. Cerebellum 15:491-7 |
| Shaikh, Aasef G (2016) Abnormal head oscillations in neuro-ophthalmology and neuro-otology. Curr Opin Neurol 29:94-103 |
| Shaikh, Aasef G; Otero-Millan, Jorge; Kumar, Priyanka et al. (2016) Abnormal Fixational Eye Movements in Amblyopia. PLoS One 11:e0149953 |
| Shaikh, Aasef G; Ghasia, Fatema F; DeLong, Mahlon R et al. (2015) Ocular palatal tremor plus dystonia - new syndromic association. Mov Disord Clin Pract 2:267-270 |
| Shaikh, Aasef G; Ghasia, Fatema F (2015) Neuro-ophthalmology of type 1 Chiari malformation. Expert Rev Ophthalmol 10:351-357 |
| Ghasia, Fatema F; Shaikh, Aasef G; Jacobs, Jonathan et al. (2015) Cross-coupled eye movement supports neural origin of pattern strabismus. Invest Ophthalmol Vis Sci 56:2855-66 |
| McCamy, Michael B; Otero-Millan, Jorge; Leigh, R John et al. (2015) Simultaneous recordings of human microsaccades and drifts with a contemporary video eye tracker and the search coil technique. PLoS One 10:e0128428 |
| Shaikh, Aasef G; Ghasia, Fatema F (2014) Gaze holding after anterior-inferior temporal lobectomy. Neurol Sci 35:1749-56 |
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