Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007975-08
Application #
2161788
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1989-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Louisville
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292
Grami, Vahid; Marrero, Yernan; Huang, Li et al. (2005) alpha-Crystallin binding in vitro to lipids from clear human lenses. Exp Eye Res 81:138-46
Huang, Li; Grami, Vahid; Marrero, Yernan et al. (2005) Human lens phospholipid changes with age and cataract. Invest Ophthalmol Vis Sci 46:1682-9
Cenedella, Richard J; Jacob, Robert; Borchman, Douglas et al. (2004) Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. J Lipid Res 45:1232-41
Borchman, Douglas; Yappert, Marta C; Afzal, Muhammad (2004) Lens lipids and maximum lifespan. Exp Eye Res 79:761-8
Tang, Daxin; Borchman, Douglas; Yappert, Marta C et al. (2003) Influence of age, diabetes, and cataract on calcium, lipid-calcium, and protein-calcium relationships in human lenses. Invest Ophthalmol Vis Sci 44:2059-66
Tang, Daxin; Borchman, Douglas; Schwarz, Arne K et al. (2003) Light scattering of human lens vesicles in vitro. Exp Eye Res 76:605-12
Borchman, Douglas; Sinha, Santosh (2002) Determination of products of lipid oxidation by infrared spectroscopy. Methods Mol Biol 186:21-8
Byrdwell, William C; Sato, Hidetoshi; Schwarz, Arne K et al. (2002) 31P NMR quantification and monophasic solvent purification of human and bovine lens phospholipids. Lipids 37:1087-92
Borchman, D; Giblin, F J; Leverenz, V R et al. (2000) Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipids and nuclear light scatter. Invest Ophthalmol Vis Sci 41:3061-73
Zhang, Z; Zeng, J; Yin, H et al. (1999) Membrane lipid alpha-crystallin interaction and membrane Ca2+ -ATPase activities. Curr Eye Res 18:56-61

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