Abstract

This proposal outlines psychophysical research techniques designed to study the changes in human color vision associated with primary open angle glaucoma. An improved understanding of the underlying functional changes in color vision caused by glaucoma will be addressed by measurement of fine discriminations along both chromatic and achromatic dimensions. Color perimetry using the procedures described in this proposal has been found to successfully differentiate glaucoma suspect and primary open angle glaucoma patients from normal age-matched controls. Long-term follow-up of these patients will determine the ability of the test to predict which ocular hypertensive eyes are most at risk for development glaucoma before topographic changes in the optic disc and standard visual field become apparent, and whether the test can used to monitor effectiveness of medical therapies employed in glaucoma. Finally, methods are incorporated which will determine the proportion of sensitivity loss due to normal aging on both standard white-on-white and color visual fields. Differentiation of age-related changes due to increased absorption of light by the ocular media and those due to retinal or neural changes will be possible. This will provide new information to assist in accurate diagnosis and treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008208-03
Application #
3265418
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Bailey, Jessica N Cooke; Gharahkhani, Puya; Kang, Jae H et al. (2018) Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest Ophthalmol Vis Sci 59:629-636
Garg, Aakriti; De Moraes, C Gustavo; Cioffi, George A et al. (2018) Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss. Am J Ophthalmol 187:92-98
Khawaja, Anthony P; Cooke Bailey, Jessica N; Wareham, Nicholas J et al. (2018) Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat Genet 50:778-782
Bowd, Christopher; Zangwill, Linda M; Weinreb, Robert N et al. (2017) Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma. Am J Ophthalmol 175:37-44
Wu, Zhichao; Saunders, Luke J; Daga, Fábio B et al. (2017) Frequency of Testing to Detect Visual Field Progression Derived Using a Longitudinal Cohort of Glaucoma Patients. Ophthalmology 124:786-792
De Moraes, C Gustavo; Hood, Donald C; Thenappan, Abinaya et al. (2017) 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology 124:1449-1456
Yousefi, Siamak; Balasubramanian, Madhusudhanan; Goldbaum, Michael H et al. (2016) Unsupervised Gaussian Mixture-Model With Expectation Maximization for Detecting Glaucomatous Progression in Standard Automated Perimetry Visual Fields. Transl Vis Sci Technol 5:2
Skaat, Alon; De Moraes, Carlos Gustavo; Bowd, Christopher et al. (2016) African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy. Ophthalmology 123:1476-83
Pasquale, Louis R (2016) Vascular and autonomic dysregulation in primary open-angle glaucoma. Curr Opin Ophthalmol 27:94-101
Silverman, Anna L; Hammel, Naama; Khachatryan, Naira et al. (2016) Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. Ophthalmology 123:408-14

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