Abstract

The long-term goal of our research is to understand how the visual system decides where to look. The activity of multiple neurons will be monitored simultaneously in monkeys performing visual search tasks designed to dissociate visual processing from saccade preparation. The frontal eye field will be studied because it is situated anatomically to sample the outcome of visual processing to orient attention and produce motor commands to orient gaze. Patterns of neural activity will be analyzed to evaluate specific hypotheses about how visual information is encoded for target selection among pools of neurons (Aim 1), to describe how sensory-motor mapping occurs between visual and saccade neurons (Aim 2) and to determine how short-term and long-term experience influences saccade target selection (Aim 3). Understanding how the brain selects visual stimuli for action is necessary to understand the causes of impaired visual behavior. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008890-18
Application #
7434319
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Oberdorfer, Michael
Project Start
1991-01-01
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
18
Fiscal Year
2008
Total Cost
$365,181
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Cosman, Joshua D; Lowe, Kaleb A; Zinke, Wolf et al. (2018) Prefrontal Control of Visual Distraction. Curr Biol 28:414-420.e3
Cosman, Joshua D; Lowe, Kaleb A; Zinke, Wolf et al. (2018) Prefrontal Control of Visual Distraction. Curr Biol 28:1330
Schall, Jeffrey D; Palmeri, Thomas J; Logan, Gordon D (2017) Models of inhibitory control. Philos Trans R Soc Lond B Biol Sci 372:
Nelson, Matthew J; Murthy, Aditya; Schall, Jeffrey D (2016) Neural control of visual search by frontal eye field: chronometry of neural events and race model processes. J Neurophysiol 115:1954-69
Logan, Gordon D; Yamaguchi, Motonori; Schall, Jeffrey D et al. (2015) Inhibitory control in mind and brain 2.0: blocked-input models of saccadic countermanding. Psychol Rev 122:115-47
Neggers, S F W; Zandbelt, B B; Schall, M S et al. (2015) Comparative diffusion tractography of corticostriatal motor pathways reveals differences between humans and macaques. J Neurophysiol 113:2164-72
Heitz, Richard P; Schall, Jeffrey D (2013) Neural chronometry and coherency across speed-accuracy demands reveal lack of homomorphism between computational and neural mechanisms of evidence accumulation. Philos Trans R Soc Lond B Biol Sci 368:20130071
Schall, Jeffrey D (2013) Macrocircuits: decision networks. Curr Opin Neurobiol 23:269-74
Purcell, Braden A; Schall, Jeffrey D; Woodman, Geoffrey F (2013) On the origin of event-related potentials indexing covert attentional selection during visual search: timing of selection by macaque frontal eye field and event-related potentials during pop-out search. J Neurophysiol 109:557-69
Reinhart, Robert M G; Heitz, Richard P; Purcell, Braden A et al. (2012) Homologous mechanisms of visuospatial working memory maintenance in macaque and human: properties and sources. J Neurosci 32:7711-22

Showing the most recent 10 out of 67 publications