In the 1960s Barlow developed the efficient coding hypothesis, arguing that the function of sensory encoding is to maximize the efficiency with which neural signals are transmitted. "The principle of recoding [visual-sensory events into neural signals] is to find what images are expected on the basis of past experience and then to ... reserve the outputs with many impulses for the unusual or unexpected inputs." To guide visual behavior, movements of the eyes, efficiently encoded sensory signals in the striate and extra-striate cortex must be combined with stored estimates of the value, to the organism, of the actions associated with those signals. Perhaps surprisingly however, studies of the visual-saccadic system have lagged behind studies of the striate and extrastriate cortices in this regard. We know almost nothing about how reward-related saccadic signals are encoded, and this means that we have almost no understanding of how injuries and diseases that devastate brain areas ranging from the basal ganglia to the parietal cortex can be addressed by behavioral treatments. Here we propose to begin the formal study of neural coding in the saccadic system by programmatically assessing the efficiency with which the nervous system encodes information about the rewards that guide saccadic behavior in a way that will allow us to test several competing contemporary hypotheses about the function of the basal ganglia and the parietal cortex. We propose to test hypotheses about the roles of these brain areas in learning, storing, and representing the values of actions. Finally, we propose a set of causal interventions in brain activity to test the hypotheses developed by these behavioral and physiological experiments. We therefore propose to study 1) the midbrain dopamine neurons, 2) the visual-saccadic striatum (both the caudate and the ventral striatum) and 3) the lateral intra-parietal area.

Public Health Relevance

Patients with Parkinson's disease and other basal ganglia disorders are crippled by dysfunctional, or inefficient, movement generation. These patients also show aberrant reinforcement learning, although we do not now have a way of assessing the loss in learning efficiency that is associated with these diseases or how directly their deficit is related to learning. Relating activity in these areas to learning will allow us both to assess these deficits more accurately, and to relate measurable dysfunctions in learning to the well studied and crippling dysfunctions of movement that these patients suffer.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010536-17
Application #
8403613
Study Section
Special Emphasis Panel (ZRG1-IFCN-B (02))
Program Officer
Steinmetz, Michael A
Project Start
1995-07-01
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
17
Fiscal Year
2013
Total Cost
$347,577
Indirect Cost
$121,857
Name
New York University
Department
Neurology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Grattan, Lauren E; Glimcher, Paul W (2014) Absence of spatial tuning in the orbitofrontal cortex. PLoS One 9:e112750
Yamada, Hiroshi; Tymula, Agnieszka; Louie, Kenway et al. (2013) Thirst-dependent risk preferences in monkeys identify a primitive form of wealth. Proc Natl Acad Sci U S A 110:15788-93
Louie, Kenway; Grattan, Lauren E; Glimcher, Paul W (2011) Reward value-based gain control: divisive normalization in parietal cortex. J Neurosci 31:10627-39
Yamada, Hiroshi; Louie, Kenway; Glimcher, Paul W (2010) Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality. J Neurosci Methods 191:83-9
Kable, Joseph W; Glimcher, Paul W (2009) The neurobiology of decision: consensus and controversy. Neuron 63:733-45
Rutledge, Robb B; Lazzaro, Stephanie C; Lau, Brian et al. (2009) Dopaminergic drugs modulate learning rates and perseveration in Parkinson's patients in a dynamic foraging task. J Neurosci 29:15104-14
Lau, Brian; Glimcher, Paul W (2008) Value representations in the primate striatum during matching behavior. Neuron 58:451-63
Bayer, Hannah M; Lau, Brian; Glimcher, Paul W (2007) Statistics of midbrain dopamine neuron spike trains in the awake primate. J Neurophysiol 98:1428-39
Lau, Brian; Glimcher, Paul W (2005) Dynamic response-by-response models of matching behavior in rhesus monkeys. J Exp Anal Behav 84:555-79
Glimcher, Paul W; Dorris, Michael C; Bayer, Hannah M (2005) Physiological utility theory and the neuroeconomics of choice. Games Econ Behav 52:213-256

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