Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY012018-07
Application #
6700866
Study Section
Visual Sciences A Study Section (VISA)
Program Officer
Liberman, Ellen S
Project Start
1998-02-01
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
7
Fiscal Year
2004
Total Cost
$339,750
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Mishra, Sanjay; Chandler, Shane A; Williams, Dewight et al. (2018) Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity. Structure 26:1116-1126.e4
Mishra, Sanjay; Wu, Shu-Yu; Fuller, Alexandra W et al. (2018) Loss of ?B-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. J Biol Chem 293:740-753
Wu, Shu-Yu; Zou, Ping; Fuller, Alexandra W et al. (2016) Expression of Cataract-linked ?-Crystallin Variants in Zebrafish Reveals a Proteostasis Network That Senses Protein Stability. J Biol Chem 291:25387-25397
Koteiche, Hanane A; Claxton, Derek P; Mishra, Sanjay et al. (2015) Species-Specific Structural and Functional Divergence of ?-Crystallins: Zebrafish ?Ba- and Rodent ?A(ins)-Crystallin Encode Activated Chaperones. Biochemistry 54:5949-58
Anderson, David M G; Floyd, Kyle A; Barnes, Stephen et al. (2015) A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: application to small vertebrate lens imaging. Anal Bioanal Chem 407:2311-20
Zou, Ping; Wu, Shu-Yu; Koteiche, Hanane A et al. (2015) A conserved role of ?A-crystallin in the development of the zebrafish embryonic lens. Exp Eye Res 138:104-13
Shi, Jian; Koteiche, Hanane A; McDonald, Ezelle T et al. (2013) Cryoelectron microscopy analysis of small heat shock protein 16.5 (Hsp16.5) complexes with T4 lysozyme reveals the structural basis of multimode binding. J Biol Chem 288:4819-30
Yirdaw, Robel B; McHaourab, Hassane S (2012) Direct observation of T4 lysozyme hinge-bending motion by fluorescence correlation spectroscopy. Biophys J 103:1525-36
Mishra, Sanjay; Stein, Richard A; McHaourab, Hassane S (2012) Cataract-linked ýýD-crystallin mutants have weak affinity to lens chaperones ýý-crystallins. FEBS Lett 586:330-6
McHaourab, Hassane S; Lin, Yi-Lun; Spiller, Benjamin W (2012) Crystal structure of an activated variant of small heat shock protein Hsp16.5. Biochemistry 51:5105-12

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