The central nervous system (CNS) of people has only a limited capacity to regenerate after traumatic damage or degenerative diseases. However, in the past few years several lines of evidence have shown that new neurons are generated in the brains of higher vertebrates, and even humans. While the amount of neurogenesis that occurs in adults is limited, the capacity for stimulating this process for repair and regeneration is just beginning to be explored. We have found that the retina of the post hatch chick is capable of a limited amount of regeneration. In the past year we have also discovered a similar process in the rat and mouse retina. In this proposal we outline experiments that will lead to a better understanding of the molecular factors that regulate glial proliferation, and the mechanisms by which they maintain their phenotype. We also will attempt to define the basis for their plasticity and ability to serve as retinal progenitors and as a substrate for retinal regeneration. We use the retina, an easily accessible part of the central nervous system, as a model for the rest of the CNS. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY013475-07
Application #
7418281
Study Section
Neurogenesis and Cell Fate Study Section (NCF)
Program Officer
Greenwell, Thomas
Project Start
2001-04-01
Project End
2011-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
7
Fiscal Year
2008
Total Cost
$365,915
Indirect Cost
Name
University of Washington
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Hartman, Byron H; Nelson, Branden R; Reh, Thomas A et al. (2010) Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear. J Assoc Res Otolaryngol 11:187-201
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Brzezinski 4th, Joseph A; Lamba, Deepak A; Reh, Thomas A (2010) Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development 137:619-29
Georgi, Sean A; Reh, Thomas A (2010) Dicer is required for the transition from early to late progenitor state in the developing mouse retina. J Neurosci 30:4048-61

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