The study will investigate how visual information is represented in the prefrontal cortex, the brain area involved with higher cognitive functions, before and after learning to perform a cognitive task. Monkeys will be trained in cognitive tasks that require them to observe and remember visual stimuli. Neurophysiological recordings with an array of microelectrodes at various training stages will allow us to determine the patterns of neuronal activation and the functional interactions between neurons. The experiments will uncover the nature of changes that take place in the prefrontal cortex by learning to perform a cognitive task.

Public Health Relevance

The experiments will test what changes occur in the prefrontal cortex after subjects are trained to perform a cognitive task that requires visual, short-term memory. Cognitive training has shown promise in restoring function after traumatic brain injury, in ameliorating the effects of normal aging, and improving cognitive symptoms of disorders such as Alzheimer's disease. Our results will uncover the changes in brain circuits following cognitive training and offer insights on the design of better treatment strategies for dealing with cognitive decline associated with these conditions.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Special Emphasis Panel (SPC)
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Steinmetz, Michael A
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Wake Forest University Health Sciences
Anatomy/Cell Biology
Schools of Medicine
United States
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Zhou, Xin; Constantinidis, Christos (2017) Fixation target representation in prefrontal cortex during the antisaccade task. J Neurophysiol 117:2152-2162
Tang, Hua; Riley, Mitchell R; Constantinidis, Christos (2017) Lateralization of Executive Function: Working Memory Advantage for Same Hemifield Stimuli in the Monkey. Front Neurosci 11:532
Murray, John D; Bernacchia, Alberto; Roy, Nicholas A et al. (2017) Stable population coding for working memory coexists with heterogeneous neural dynamics in prefrontal cortex. Proc Natl Acad Sci U S A 114:394-399
Zhou, Xin; Zhu, Dantong; Qi, Xue-Lian et al. (2016) Neural correlates of working memory development in adolescent primates. Nat Commun 7:13423
Constantinidis, Christos; Klingberg, Torkel (2016) The neuroscience of working memory capacity and training. Nat Rev Neurosci 17:438-49
Riley, Mitchell R; Constantinidis, Christos (2015) Role of Prefrontal Persistent Activity in Working Memory. Front Syst Neurosci 9:181
Katsuki, Fumi; Qi, Xue-Lian; Meyer, Travis et al. (2014) Differences in intrinsic functional organization between dorsolateral prefrontal and posterior parietal cortex. Cereb Cortex 24:2334-49
Zhou, Xin; Zhu, Dantong; Katsuki, Fumi et al. (2014) Age-dependent changes in prefrontal intrinsic connectivity. Proc Natl Acad Sci U S A 111:3853-8
Katsuki, Fumi; Constantinidis, Christos (2013) Time course of functional connectivity in primate dorsolateral prefrontal and posterior parietal cortex during working memory. PLoS One 8:e81601
Qi, Xue-Lian; Constantinidis, Christos (2013) Neural changes after training to perform cognitive tasks. Behav Brain Res 241:235-43

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