The visual system has emerged as a premier model for understanding information processing by neurons. Within vision, the submodality of color provides a particularly attractive experimental platform: we know a tremendous amount about the phenomenology of color perception and can explain some aspects of color perception, quantitatively and with high precision, by well- understood physiological processes. As a result of this progress, we can quickly and accurately diagnose many distinct forms of color blindness and can build devices that render colors accurately. On the other hand, surprising holes in our knowledge remain. The proposed research will fill this hole in our knowledge by determining where the temporal bottlenecks for detection and appearance reside.
Three specific aims are planned: 1) Electrophysiological and modeling to determine where in the visual system luminance signaling is limited. 2) Electrophysiological and modeling to determine where in the visual system red- green chromatic signaling is limited. 3) Comparison of stimulus categories as classified by monkeys and by their component neurons to determine whether the dynamics of neuronal signals are responsible for changes in stimulus appearance as a function of temporal frequency. The proposed experiments will extend our knowledge toward an understanding of the principles that give rise to perception and its disorders. Such an understanding promises to provide the means to promote recovery of visual function following trauma or neurological disease.

Public Health Relevance

Understanding how neurons mediate perception is an important step towards developing effective treatments for pathologies that disrupt perception. The proposed experiments exploit the model system of color vision, one of the most mature submodalities of vision, to reveal the neural events that relate activation of the peripheral receptors to perception.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY018849-09
Application #
9672472
Study Section
Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
Program Officer
Flanders, Martha C
Project Start
2008-04-01
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
9
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Washington
Department
Physiology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Fetsch, Christopher R; Odean, Naomi N; Jeurissen, Danique et al. (2018) Focal optogenetic suppression in macaque area MT biases direction discrimination and decision confidence, but only transiently. Elife 7:
Weller, J Patrick; Horwitz, Gregory D (2018) Measurements of neuronal color tuning: Procedures, pitfalls, and alternatives. Vision Res 151:53-60
Hass, Charles A; Angueyra, Juan M; Lindbloom-Brown, Zachary et al. (2015) Chromatic detection from cone photoreceptors to V1 neurons to behavior in rhesus monkeys. J Vis 15:1
Horwitz, G D (2015) What studies of macaque monkeys have told us about human color vision. Neuroscience 296:110-5
Lindbloom-Brown, Zachary; Tait, Leah J; Horwitz, Gregory D (2014) Spectral sensitivity differences between rhesus monkeys and humans: implications for neurophysiology. J Neurophysiol 112:3164-72
Hass, Charles A; Horwitz, Gregory D (2013) V1 mechanisms underlying chromatic contrast detection. J Neurophysiol 109:2483-94
Jazayeri, Mehrdad; Lindbloom-Brown, Zachary; Horwitz, Gregory D (2012) Saccadic eye movements evoked by optogenetic activation of primate V1. Nat Neurosci 15:1368-70
Horwitz, Gregory D; Hass, Charles A (2012) Nonlinear analysis of macaque V1 color tuning reveals cardinal directions for cortical color processing. Nat Neurosci 15:913-9
Hass, Charles A; Horwitz, Gregory D (2011) Effects of microsaccades on contrast detection and V1 responses in macaques. J Vis 11:1-17
Conway, Bevil R; Chatterjee, Soumya; Field, Greg D et al. (2010) Advances in color science: from retina to behavior. J Neurosci 30:14955-63