The goal of this competitive renewal is to translate laboratory research on wavefront-guided scleral contact lenses into a clinical solution for highly aberrated eyes that restores retinal image quality to normal or better than normal levels. This will be accomplished by identifying and removing barriers that currently complicate clinical translation. Completion of this goal will allow the research team to test the hypotheses that: 1) A mature visual system (having experienced good retinal image quality during the formative years) that is now habitually experiencing poor retinal image quality due to elevated higher order aberrations will, with time, adapt back to normal levels of visual performance (visual acuity, contrast sensitivity as a function of letter size and stereo-acuity); and 2) normal or better than normal retinal image quality provided by wavefront guided corrections improves quality of life in patients with highly aberrated eyes compared to clinically available non-wavefront guided corrections.

Public Health Relevance

Typical causes of highly aberrated eyes (keratoconus, corneal marginal dystrophy, poor refractive surgery outcome, etc.) occur during the most productive years of life (years of education, earning power, child bearing). The work proposed here immediately transfers laboratory research into clinical care that reduces visual impairment by improving the quality of vision to normal levels in these individuals and increases our understanding of the visual system.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY019105-08
Application #
9511833
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Wiggs, Cheri
Project Start
2009-04-01
Project End
2019-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Houston
Department
Type
Schools of Optometry/Opht Tech
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Hastings, Gareth D; Marsack, Jason D; Nguyen, Lan Chi et al. (2017) Is an objective refraction optimised using the visual Strehl ratio better than a subjective refraction? Ophthalmic Physiol Opt 37:317-325
Ticak, Anita; Marsack, Jason D; Koenig, Darren E et al. (2015) A Comparison of Three Methods to Increase Scleral Contact Lens On-Eye Stability. Eye Contact Lens 41:386-90
Marsack, Jason D; Ravikumar, Ayeswarya; Nguyen, Chi et al. (2014) Wavefront-guided scleral lens correction in keratoconus. Optom Vis Sci 91:1221-30
Bradley, Arthur; Xu, Renfeng; Thibos, Larry et al. (2014) Influence of spherical aberration, stimulus spatial frequency, and pupil apodisation on subjective refractions. Ophthalmic Physiol Opt 34:309-20
Shi, Yue; Applegate, Raymond A; Wei, Xin et al. (2013) Registration tolerance of a custom correction to maintain visual acuity. Optom Vis Sci 90:1370-84
Marsack, Jason D; Rozema, Jos J; Koppen, Carina et al. (2013) Template-based correction of high-order aberration in keratoconus. Optom Vis Sci 90:324-34
Shi, Yue; Queener, Hope M; Marsack, Jason D et al. (2013) Optimizing wavefront-guided corrections for highly aberrated eyes in the presence of registration uncertainty. J Vis 13:
Koenig, Darren E; Nguyen, Lan Chi; Parker, Katrina E et al. (2013) Factors accounting for the 4-year change in acuity in patients between 50 and 80 years. Optom Vis Sci 90:620-7
Ravikumar, Ayeswarya; Marsack, Jason D; Bedell, Harold E et al. (2013) Change in visual acuity is well correlated with change in image-quality metrics for both normal and keratoconic wavefront errors. J Vis 13:28
Ravikumar, Ayeswarya; Sarver, Edwin J; Applegate, Raymond A (2012) Change in visual acuity is highly correlated with change in six image quality metrics independent of wavefront error and/or pupil diameter. J Vis 12:11

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