This is a proposal for competitive renewal of the currently funded R01 grant entitled "Systematic psychophysical investigation of visual learning". Visual perceptual learning (VPL) is regarded as a promising tool that can help clarify important aspects of visual and brain plasticity. Our long-term goal is to delineate general rules that govern VPL, and to gain a better understanding of the mechanisms of visual and brain plasticity. During the currently supported period, we have attained great success in clarifying the characteristics of perceptual and behavioral changes under VPL, often by examining how performance at or around a trained feature value is changed as a result of visual training. However, new serious controversies about the mechanisms of VPL have emerged. One controversy concerns the locus of VPL, or the visual and brain information processing stage that is changed in association with VPL. The other concerns how VPL with location specificity or transfer is developed during training. We will conduct systematic psychophysical research with the aim of building two separate but related models, each of which concerns where or how VPL is developed to resolve each of these controversies, so that these two models will be integrated to a unified model of VPL.
In Aim 1, we will attempt to resolve the controversy about the locus of VPL by developing a two-stage model that can account for both the findings that support low-level changes and those that support higher-level stages, without denying either evidence for the low-level or higher-level models. By conducting a variety of experiments with different types of tasks, stimuli and procedures, we will psychophysically test the validity of this two-stage model as well as existing models.
In Aim 2, we will attempt to resolve the second controversy. The reduction of the degree of location specificity by double training has exposed serious limitations in how existing models explain location specificity. Thus far, no theoretical model has been proposed that can clearly explain how location specificity occurs by single training, as well as how location specificity is weakened/eliminated by double training. Based on our recent finding of elimination of VPL followed by reactivation and our influential reinforcement model, we will build the reinforcement reactivation model that assumes that the elimination of location specificity after double training is due to a failure to reconsolidate location specific learning tat was reactivated by reinforcement signals. In a series of experiments, we will test the validity of this reinforcement reactivation model and other existing models. In both aims, results of experiments will also be used to further refine the proposed models to most suitably account for where and how VPL is developed. Examinations of these aims will help to achieve our long-term goal of clarifying general functional rules that govern VPL.

Public Health Relevance

The project systematically examines visual perceptual learning (VPL) using a unified psychophysical method to develop new models to resolve serious controversies in the research on VPL and to test the validity of these models and existing models. The current proposal investigates: how the conflict regarding which information processing stage is changed in association of VPL can be resolved and the question concerning how the specificity and transfer in VPL in different conditions occur can be answered. The resulting scientific knowledge may lead to improved diagnoses of, and rehabilitative therapies for, brain disorders and lesions, in particular those related to visual function.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Special Emphasis Panel (SPC)
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Wiggs, Cheri
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Brown University
Schools of Arts and Sciences
United States
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Watanabe, Takeo; Sasaki, Yuka (2015) Perceptual learning: toward a comprehensive theory. Annu Rev Psychol 66:197-221
Kawato, Mitsuo; Lu, Zhong-Lin; Sagi, Dov et al. (2014) Perceptual learning--the past, present and future. Vision Res 99:1-4
Bang, Ji Won; Khalilzadeh, Omid; Hämäläinen, Matti et al. (2014) Location specific sleep spindle activity in the early visual areas and perceptual learning. Vision Res 99:162-71
Chang, Li-Hung; Shibata, Kazuhisa; Andersen, George J et al. (2014) Age-related declines of stability in visual perceptual learning. Curr Biol 24:2926-9
Choi, Hoon; Watanabe, Takeo (2014) Can attenuation of attentional blink also evoke removal of repetition blindness? Vision Res 99:141-7
Tamaki, Masako; Bang, Ji Won; Watanabe, Takeo et al. (2014) The first-night effect suppresses the strength of slow-wave activity originating in the visual areas during sleep. Vision Res 99:154-61
Yotsumoto, Yuko; Chang, Li-Hung; Ni, Rui et al. (2014) White matter in the older brain is more plastic than in the younger brain. Nat Commun 5:5504
Shibata, Kazuhisa; Sagi, Dov; Watanabe, Takeo (2014) Two-stage model in perceptual learning: toward a unified theory. Ann N Y Acad Sci 1316:18-28
Choi, Hoon; Watanabe, Takeo (2012) Perceptual learning solely induced by feedback. Vision Res 61:77-82
Liu, Charles C; Watanabe, Takeo (2012) Accounting for speed-accuracy tradeoff in perceptual learning. Vision Res 61:107-14

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