Human visual event-related potentials (ERPs) measure a variety of different cognitive operations during visual processing. Visual ERPs are invaluable in diagnosing and studying neurological and psychopathological disorders in addition to revealing how the health brain turns visual inputs into appropriate responses. However, it has proven very difficult to definitively determine what brain areas generate specific ERP components related to deploying visual attention and monitoring task performance. We propose to directly locate the sources of ERP components elicited during visual processing and task performance using both humans and nonhuman primates. In the latter we will record noninvasive ERPs simultaneously with intracranial recordings of local field potentials. Preliminary evidence from monkeys and humans performing identical visual tasks demonstrates homology between human and macaque ERP components indexing visual attentional deployment and performance monitoring. By concurrently studying humans and monkeys this project will allow clinicians and health researchers to use the visually and response evoked ERP components recorded noninvasively from humans to access whether specific brain regions are functioning properly and also to develop animal models of specific disorders.

Public Health Relevance

The overall goal of this research program is to perform comparative studies of humans and monkeys using common electrophysiological measures. Then, to develop techniques to determine whether nonhuman primates exhibit event-related potentials indexing the same cognitive processes as those used to study mental and other health disorders in humans. Preliminary evidence suggests these may exist and the present project will use humans and monkeys to determine where in the brain these potentials are generated. These methods will provide a way for health researchers to develop animal models of human health disorders, discover underlying causes, and test potential treatments.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY019882-01
Application #
7765428
Study Section
Special Emphasis Panel (ZRG1-IFCN-L (02))
Program Officer
Steinmetz, Michael A
Project Start
2009-12-01
Project End
2013-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
1
Fiscal Year
2010
Total Cost
$375,198
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Reinhart, Robert M G; Cosman, Josh D; Fukuda, Keisuke et al. (2017) Using transcranial direct-current stimulation (tDCS) to understand cognitive processing. Atten Percept Psychophys 79:3-23
Fukuda, Keisuke; Woodman, Geoffrey F (2017) Visual working memory buffers information retrieved from visual long-term memory. Proc Natl Acad Sci U S A 114:5306-5311
Reinhart, Robert M G; McClenahan, Laura J; Woodman, Geoffrey F (2016) Attention's Accelerator. Psychol Sci 27:790-8
Fukuda, Keisuke; Kang, Min-Suk; Woodman, Geoffrey F (2016) Distinct neural mechanisms for spatially lateralized and spatially global visual working memory representations. J Neurophysiol 116:1715-1727
Cosman, Joshua D; Arita, Jason T; Ianni, Julianna D et al. (2016) Electrophysiological measurement of information flow during visual search. Psychophysiology 53:535-43
Reinhart, Robert M G; Xiao, Wenxi; McClenahan, Laura J et al. (2016) Electrical Stimulation of Visual Cortex Can Immediately Improve Spatial Vision. Curr Biol 26:1867-72
Reinhart, Robert M G; Zhu, Julia; Park, Sohee et al. (2015) Medial-Frontal Stimulation Enhances Learning in Schizophrenia by Restoring Prediction Error Signaling. J Neurosci 35:12232-40
Cosman, Joshua D; Atreya, Priyanka V; Woodman, Geoffrey F (2015) Transient reduction of visual distraction following electrical stimulation of the prefrontal cortex. Cognition 145:73-6
Maxcey, Ashleigh M; Fukuda, Keisuke; Song, Won S et al. (2015) Using electrophysiology to demonstrate that cueing affects long-term memory storage over the short term. Psychon Bull Rev 22:1349-57
Reinhart, Robert M G; Zhu, Julia; Park, Sohee et al. (2015) Synchronizing theta oscillations with direct-current stimulation strengthens adaptive control in the human brain. Proc Natl Acad Sci U S A 112:9448-53

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