This program continues investigations in synthetic and mechanistic organic chemistry. These studies are of general medicinal interest relating to substances which are antifungal, antineoplastic, and antibacterial agents and vitamins. Several of the substances of this type include carbomycin B, tirandamycin, streptolydigin, pyrenophorin, vermiculin among the antibiotics and vitamins E and K which will serve as models for mechanistic studies. A major facet of the program involves the use of sigmatropic rearrangments to control stereochemistry in the tirandamycin, streptolydigin, and vitamin work. Palladium-mediated, ambient temperature coupling reactions developed in this laboratory will be applied in the synthetic program related to carbomycin B, pyrenophorin, and vermiculin.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033180-05
Application #
3282563
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1984-06-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code