Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM037106-01A2
Application #
3292112
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1988-03-01
Project End
1988-08-15
Budget Start
1988-03-01
Budget End
1988-08-15
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Maryland Balt CO Campus
Department
Type
Schools of Arts and Sciences
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21250
Topcu, Z; Castora, F J (1995) Mammalian mitochondrial DNA topoisomerase I preferentially relaxes supercoils in plasmids containing specific mitochondrial DNA sequences. Biochim Biophys Acta 1264:377-87
Lin, J H; Castora, F J (1995) Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and m-AMSA. Arch Biochem Biophys 324:293-9
Staub, J M; Castora, F J (1993) Mammalian mitochondrial DNA sequences can function as in vivo bacterial transcription terminators. Biochem Biophys Res Commun 192:616-26
Ciavarra, R P; Duvall, W; Castora, F J (1992) Induction of thermotolerance in T cells protects nuclear DNA topoisomerase I from heat stress. Biochem Biophys Res Commun 186:166-72
Lin, J H; Lazarus, G M; Castora, F J (1992) DNA topoisomerase I from calf thymus mitochondria is associated with a DNA binding, inner membrane protein. Arch Biochem Biophys 293:201-7
Castora, F J; Erickson, C E; Kovacs, T et al. (1991) 2',5'-oligoadenylates inhibit relaxation of supercoiled DNA by calf thymus DNA topoisomerase I. J Interferon Res 11:143-9
Lin, J H; Castora, F J (1991) DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26. Biochem Biophys Res Commun 176:690-7
Staub, J M; Castora, F J (1990) Identification of transcription promoter regions from rat mtDNA that are utilized in vivo by the bacterial RNA polymerase. Biochem Biophys Res Commun 172:1282-90