Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM038627-02
Application #
3295189
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1987-07-01
Project End
1988-08-31
Budget Start
1988-07-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Viswanathan, Vasanthi S; Ryan, Matthew J; Dhruv, Harshil D et al. (2017) Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547:453-457
Leshchiner, Elizaveta S; Rush, Jason S; Durney, Michael A et al. (2017) Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease. Proc Natl Acad Sci U S A 114:11392-11397
Nelson Jr, Shawn D; Wawer, Mathias J; Schreiber, Stuart L (2016) Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives. Org Lett 18:6280-6283
Wagner, Bridget K; Schreiber, Stuart L (2016) The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods. Cell Chem Biol 23:3-9
Hideshima, Teru; Qi, Jun; Paranal, Ronald M et al. (2016) Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A 113:13162-13167
Gerry, Christopher J; Hua, Bruce K; Wawer, Mathias J et al. (2016) Real-Time Biological Annotation of Synthetic Compounds. J Am Chem Soc 138:8920-7
Boskovic, Zarko V; Kemp, Melissa M; Freedy, Allyson M et al. (2016) Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol 11:1844-51
Haftchenary, Sina; Nelson Jr, Shawn D; Furst, Laura et al. (2016) Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments. ACS Comb Sci 18:569-74
Chattopadhyay, Shrikanta; Stewart, Alison L; Mukherjee, Siddhartha et al. (2015) Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep :
Scully, Stephen S; Zheng, Shao-Liang; Wagner, Bridget K et al. (2015) Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides. Org Lett 17:418-21

Showing the most recent 10 out of 102 publications