Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043214-06
Application #
2181882
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1991-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Wendlandt, Alison E; Vangal, Prithvi; Jacobsen, Eric N (2018) Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction. Nature 556:447-451
Zhou, Biying; Haj, Moriana K; Jacobsen, Eric N et al. (2018) Mechanism and Origins of Chemo- and Stereoselectivities of Aryl Iodide-Catalyzed Asymmetric Difluorinations of ?-Substituted Styrenes. J Am Chem Soc 140:15206-15218
Kwan, Eugene E; Zeng, Yuwen; Besser, Harrison A et al. (2018) Concerted nucleophilic aromatic substitutions. Nat Chem 10:917-923
Mennie, Katrina M; Banik, Steven M; Reichert, Elaine C et al. (2018) Catalytic Diastereo- and Enantioselective Fluoroamination of Alkenes. J Am Chem Soc 140:4797-4802
Banik, Steven M; Levina, Anna; Hyde, Alan M et al. (2017) Lewis acid enhancement by hydrogen-bond donors for asymmetric catalysis. Science 358:761-764
Klausen, Rebekka S; Kennedy, C Rose; Hyde, Alan M et al. (2017) Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction. J Am Chem Soc 139:12299-12309
Banik, Steven M; Mennie, Katrina M; Jacobsen, Eric N (2017) Catalytic 1,3-Difunctionalization via Oxidative C-C Bond Activation. J Am Chem Soc 139:9152-9155
Park, Yongho; Harper, Kaid C; Kuhl, Nadine et al. (2017) Macrocyclic bis-thioureas catalyze stereospecific glycosylation reactions. Science 355:162-166
Kwan, Eugene E; Park, Yongho; Besser, Harrison A et al. (2017) Sensitive and Accurate 13C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer. J Am Chem Soc 139:43-46
Park, Yongho; Schindler, Corinna S; Jacobsen, Eric N (2016) Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-Bond Donor and Lewis Base. J Am Chem Soc 138:14848-14851

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