Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM045415-01A1
Application #
3304890
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1992-02-01
Project End
1992-09-24
Budget Start
1992-02-01
Budget End
1992-09-24
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Rinaldi, Vera D; Bolcun-Filas, Ewelina; Kogo, Hiroshi et al. (2017) The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure. Mol Cell 67:1026-1036.e2
McNairn, Adrian J; Rinaldi, Vera D; Schimenti, John C (2017) Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog. Genetics 205:529-537
Rinaldi, Vera D; Hsieh, Kristin; Munroe, Robert et al. (2017) Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death. Genetics 206:1823-1828
Singh, Priti; Schimenti, John C (2015) The genetics of human infertility by functional interrogation of SNPs in mice. Proc Natl Acad Sci U S A 112:10431-6
Singh, Priti; Schimenti, John C; Bolcun-Filas, Ewelina (2015) A mouse geneticist's practical guide to CRISPR applications. Genetics 199:1-15
Luo, Yunhai; Hartford, Suzanne A; Zeng, Ruizhu et al. (2014) Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS Genet 10:e1004471
Bolcun-Filas, Ewelina; Rinaldi, Vera D; White, Michelle E et al. (2014) Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science 343:533-6
Handel, Mary Ann; Eppig, John J; Schimenti, John C (2014) Applying ""gold standards"" to in-vitro-derived germ cells. Cell 157:1257-61
Qiao, Huanyu; Prasada Rao, H B D; Yang, Ye et al. (2014) Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet 46:194-9
Schimenti, Kerry J; Feuer, Sky K; Griffin, Laurie B et al. (2013) AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics 194:447-57

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