Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM046732-01A2
Application #
2184218
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Leroy, Emilie; Defour, Jean-Philippe; Sato, Takeshi et al. (2016) His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor. J Biol Chem 291:2974-87
Matsushita, Chihiro; Tamagaki, Hiroko; Miyazawa, Yudai et al. (2013) Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides. Proc Natl Acad Sci U S A 110:1646-51
Defour, Jean-Philippe; Itaya, Miki; Gryshkova, Vitalina et al. (2013) Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation. Proc Natl Acad Sci U S A 110:2540-5
Itaya, Miki; Brett, Ian C; Smith, Steven O (2012) Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy. Methods Mol Biol 831:333-57
Staerk, Judith; Defour, Jean-Philippe; Pecquet, Christian et al. (2011) Orientation-specific signalling by thrombopoietin receptor dimers. EMBO J 30:4398-413
Aucoin, Darryl; Camenares, Devin; Zhao, Xin et al. (2009) High-resolution 1H MAS RFDR NMR of biological membranes. J Magn Reson 197:77-86
Sato, Takeshi; Tang, Tzu-Chun; Reubins, Gabriella et al. (2009) A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc Natl Acad Sci U S A 106:1421-6
Sengupta, Parijat; Bosis, Eran; Nachliel, Esther et al. (2009) EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction. Biophys J 96:4887-95
Liu, Wei; Fei, Jeffrey Z; Kawakami, Toru et al. (2007) Structural constraints on the transmembrane and juxtamembrane regions of the phospholamban pentamer in membrane bilayers: Gln29 and Leu52. Biochim Biophys Acta 1768:2971-8
Staerk, Judith; Lacout, Catherine; Sato, Takeshi et al. (2006) An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood 107:1864-71

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