Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048241-06
Application #
2185731
Study Section
Biochemistry Study Section (BIO)
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zhou, Guo-Lei; Zhang, Haitao; Wu, Huhehasi et al. (2014) Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin. J Cell Sci 127:5052-65
Zhou, Guo-Lei; Zhang, Haitao; Field, Jeffrey (2014) Mammalian CAP (Cyclase-associated protein) in the world of cell migration: Roles in actin filament dynamics and beyond. Cell Adh Migr 8:55-9
Licciulli, Silvia; Maksimoska, Jasna; Zhou, Chun et al. (2013) FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem 288:29105-14
Abedin, Zahidur; Louis-Juste, Melissa; Stangl, Melissa et al. (2013) The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis. Mutat Res 750:121-8
Zhang, Haitao; Ghai, Pooja; Wu, Huhehasi et al. (2013) Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. J Biol Chem 288:20966-77
Abedin, Zahidur; Sen, Sushmita; Field, Jeffrey (2012) Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. Chem Res Toxicol 25:113-21
Sen, Sushmita; Bhojnagarwala, Pratik; Francey, Lauren et al. (2012) p53 Mutagenesis by benzo[a]pyrene derived radical cations. Chem Res Toxicol 25:2117-26
Ye, Diana Z; Jin, Shenghao; Zhuo, Ya et al. (2011) p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS One 6:e27637
Dummler, Bettina; Ohshiro, Kazufumi; Kumar, Rakesh et al. (2009) Pak protein kinases and their role in cancer. Cancer Metastasis Rev 28:51-63
Wang, Changhui; Zhou, Guo-Lei; Vedantam, Srilakshmi et al. (2008) Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis. J Cell Sci 121:2913-20

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