Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053270-07
Application #
2192613
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-08-03
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Physiology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Morgan, David O (2013) The D box meets its match. Mol Cell 50:609-10
Foster, Scott A; Morgan, David O (2012) The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell 47:921-32
Foe, Ian T; Foster, Scott A; Cheung, Stephanie K et al. (2011) Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol 21:1870-7
Schaefer, Jonathan B; Morgan, David O (2011) Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem 286:45186-96
Rodrigo-Brenni, Monica C; Foster, Scott A; Morgan, David O (2010) Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell 39:548-59
Matyskiela, Mary E; Morgan, David O (2009) Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell 34:68-80
Benanti, Jennifer A; Matyskiela, Mary E; Morgan, David O et al. (2009) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell 33:581-90
Tully, Gregory H; Nishihama, Ryuichi; Pringle, John R et al. (2009) The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell 20:1201-12
Enquist-Newman, Maria; Sullivan, Matt; Morgan, David O (2008) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell 30:437-46
Sullivan, Matt; Morgan, David O (2007) A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem 282:19710-5

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