The goals of this application are to gain insight into the molecular, genetic, cytogenetic and cellular processes that affect genetic instability in cells surviving exposure to ionizing radiation. The investigators will first ask whether clinically relevant doses of gamma radiation cause delayed chromosomal instability. They will subsequently investigate whether the instability is a dominant or recessive genetic trait, whether DNA double strand breaks are the molecular lesion that initiate the instability, and try to identify cytogenetic markers of instability.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054189-03
Application #
2701744
Study Section
Radiation Study Section (RAD)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Morgan, W F (2011) Radiation-induced genomic instability. Health Phys 100:280-1