R01-GM57587, which supports our mechanistic studies of SCF and APC/C ubiquitin ligases, was severely compromised by the hurricane Sandy. This application represents a request of a twelve months cost extension to allow us to recover the time lost and re-generate valuable lost reagents that were generated during the first two years after this grant was competitively renewed. These home-made reagents are absolutely required to perform the projects covered by R01-GM57587.

Public Health Relevance

Cells depend on the proper functioning of an ensemble of networked, molecular machines to control diverse processes, ranging from cell proliferation to cell death to differentiation. The ubiquitin system can rapidly degrade the modular regulatory components of these machines, contributing to the precise operation and synchronization of complex cellular processes. Given its critical role, the ubiquitin system is often deregulated in cancer cells. Thus, it is anticipated that the results of the proposed studies will have an impact on both basic science and cancer biology.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
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Hamlet, Michelle R
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New York University
Schools of Medicine
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Kanarek, Naama; Grivennikov, Sergei I; Leshets, Michael et al. (2014) Critical role for IL-1? in DNA damage-induced mucositis. Proc Natl Acad Sci U S A 111:E702-11
Choi, Byeong Hyeok; Pagano, Michele; Dai, Wei (2014) Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem 289:14066-74
Horn, Moritz; Geisen, Christoph; Cermak, Lukas et al. (2014) DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. Dev Cell 28:697-710
Bassermann, Florian; Eichner, Ruth; Pagano, Michele (2014) The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer. Biochim Biophys Acta 1843:150-62
Choi, Byeong Hyeok; Pagano, Michele; Huang, Chaunshu et al. (2014) Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. J Biol Chem 289:17951-9
Xing, Weiman; Busino, Luca; Hinds, Thomas R et al. (2013) SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 496:64-8
Jeong, Yeon-Tae; Rossi, Mario; Cermak, Lukas et al. (2013) FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. J Cell Biol 200:141-9
Kuchay, Shafi; Duan, Shanshan; Schenkein, Emily et al. (2013) FBXL2- and PTPL1-mediated degradation of p110-free p85? regulatory subunit controls the PI(3)K signalling cascade. Nat Cell Biol 15:472-80
Jeong, Yeon-Tae; Cermak, Lukas; Guijarro, Maria V et al. (2013) FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle 12:1128-32
Rossi, Mario; Duan, Shanshan; Jeong, Yeon-Tae et al. (2013) Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Mol Cell 49:1159-66

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