Abstract

R01-GM57587, which supports our mechanistic studies of SCF and APC/C ubiquitin ligases, was severely compromised by the hurricane Sandy. This application represents a request of a twelve months cost extension to allow us to recover the time lost and re-generate valuable lost reagents that were generated during the first two years after this grant was competitively renewed. These home-made reagents are absolutely required to perform the projects covered by R01-GM57587.

Public Health Relevance

Cells depend on the proper functioning of an ensemble of networked, molecular machines to control diverse processes, ranging from cell proliferation to cell death to differentiation. The ubiquitin system can rapidly degrade the modular regulatory components of these machines, contributing to the precise operation and synchronization of complex cellular processes. Given its critical role, the ubiquitin system is often deregulated in cancer cells. Thus, it is anticipated that the results of the proposed studies will have an impact on both basic science and cancer biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM057587-15S1
Application #
8667233
Study Section
Program Officer
Hamlet, Michelle R
Project Start
2014-01-01
Project End
2015-12-31
Budget Start
2014-01-01
Budget End
2015-12-31
Support Year
15
Fiscal Year
2014
Total Cost
$190,575
Indirect Cost
$78,141

  Institution

Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25:486-541
Kuchay, Shafi; Saeed, Mohsan; Giorgi, Carlotta et al. (2018) NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Rep 25:833-840.e3
Rona, Gergely; Roberti, Domenico; Yin, Yandong et al. (2018) PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. Elife 7:
Mavrommati, Ioanna; Faedda, Roberta; Galasso, Giovanni et al. (2018) ?-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep 24:3404-3412
Pae, Juhee; Cinalli, Ryan M; Marzio, Antonio et al. (2017) GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. Dev Cell 42:130-142.e7
Fehrenbacher, Nicole; Tojal da Silva, Israel; Ramirez, Craig et al. (2017) The G protein-coupled receptor GPR31 promotes membrane association of KRAS. J Cell Biol 216:2329-2338
Donato, Valerio; Bonora, Massimo; Simoneschi, Daniele et al. (2017) The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol 19:341-351
Kuchay, Shafi; Giorgi, Carlotta; Simoneschi, Daniele et al. (2017) PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature 546:554-558
D'Alessandro, Matthew; Beesley, Stephen; Kim, Jae Kyoung et al. (2017) Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein. Curr Biol 27:3454-3467.e8
Dankert, John F; Pagan, Julia K; Starostina, Natalia G et al. (2017) FEM1 proteins are ancient regulators of SLBP degradation. Cell Cycle 16:556-564

Showing the most recent 10 out of 112 publications