Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM058888-06
Application #
6696773
Study Section
Special Emphasis Panel (ZRG1-SSS-B (01))
Program Officer
Wehrle, Janna P
Project Start
1999-02-01
Project End
2007-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
6
Fiscal Year
2004
Total Cost
$287,473
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Biochemistry
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Melville, Zephan; Aligholizadeh, Ehson; McKnight, Laura E et al. (2017) X-ray crystal structure of human calcium-bound S100A1. Acta Crystallogr F Struct Biol Commun 73:215-221
Melville, Zephan; Hernández-Ochoa, Erick O; Pratt, Stephen J P et al. (2017) The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP. Biochemistry 56:2328-2337
Cavalier, Michael C; Melville, Zephan; Aligholizadeh, Ehson et al. (2016) Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography. Acta Crystallogr D Struct Biol 72:753-60
Roth, Braden M; Varney, Kristen M; Rustandi, Richard R et al. (2016) (1)H(N), (13)C, and (15)N resonance assignments of the CDTb-interacting domain (CDTaBID) from the Clostridium difficile binary toxin catalytic component (CDTa, residues 1-221). Biomol NMR Assign 10:335-9
Cavalier, Michael C; Ansari, Mohd Imran; Pierce, Adam D et al. (2016) Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. J Med Chem 59:592-608
Bresnick, Anne R; Weber, David J; Zimmer, Danna B (2015) S100 proteins in cancer. Nat Rev Cancer 15:96-109
Hartman, Kira G; Vitolo, Michele I; Pierce, Adam D et al. (2014) Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. J Biol Chem 289:12886-95
Dhar, Amlanjyoti; Mallick, Shampa; Ghosh, Piya et al. (2014) Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide. Biopolymers 102:344-58
Cavalier, Michael C; Pierce, Adam D; Wilder, Paul T et al. (2014) Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry 53:6628-40
Hartman, Kira G; McKnight, Laura E; Liriano, Melissa A et al. (2013) The evolution of S100B inhibitors for the treatment of malignant melanoma. Future Med Chem 5:97-109

Showing the most recent 10 out of 64 publications