Alkenes are found in a great number of biologically active molecules and are employed in some of the most widely used transformations used to access them (such as hydrogenations, epoxidations, hydroborations, dihydroxylations, cyclopropanations, allylic substitutions, hydroformylations and cycloadditions). Many olefins exist as E or higher energy Z isomers. Processes that allow access to each isomeric form efficiently, reliably, with high selectivity and in a cost-effective fashion are therefore of substantial significance to chemistry, biology and medicine. Especially valuable are catalytic procedures for stereoselective formation of alkenes;however, such methods are uncommon. Particularly scarce are catalytic protocols that deliver Z alkenes. Research in this program is focused on the design, synthesis and development of a range of molybdenum- and tungsten-based catalysts that can be used for one of the most powerful and efficient methods for olefin synthesis: catalytic olefin metathesis. A variety of concepts, originally conceived in this NIH-funded program, will be used to introduce catalysts that can be manipulated in air and yet offer exceptional reactivity and selectivity when placed in solution in the presence of a substrate. Such catalysts will allow chemists to obtain reactivity and/or selectivity levels that remain entirely out of reach. Olefin metathesis catalysts will be developed that promote Z-selective cross-metathesis reactions of allylic ethers, epoxides, boronates, silanes as well as vinylbornates, dienes and 1,2-unsaturated carbonyls. Catalysts will be introduced that will allow chemists to prepare Z di- or trisubstituted macrocyclic alkenes, without having to forfeit nearly half of their valuable materials as the undesired stereoisomer at the late stages of a multi-step total synthesis. The new catalysts and methods will generate entities commonly viewed as the """"""""bread and butter"""""""" of synthetic chemists, and yet their preparation often requires long and impractical routes. The special utility of the concepts, strategies, catalysts and protocols that will emerge from the proposed investigations will be highlighted through efficient approaches to syntheses of biologically significant molecules such as antimutagenic falcarindiol, antiviral chlorosufolipids, cytotoxic disorazole C1, gibberellin biosynthesis inhibitor cladospolide B, antibacterial and anticancer nakadomarin A, and anticancer agents epothilone B and neopeltolide.
Our ability to prepare various medicinally active agents in a cost-effective, reliable, efficient and selective manner is most critical to advances in human health care. The proposed research will afford unique, inexpensive and highly potent catalysts that promote efficient formation of one of the most common units found in a large number of biologically significant molecules, and that cannot be accessed easily by other methods.
|van der Mei, Farid W; Qin, Changming; Morrison, Ryan J et al. (2017) Practical, Broadly Applicable, ?-Selective, Z-Selective, Diastereoselective, and Enantioselective Addition of Allylboron Compounds to Mono-, Di-, Tri-, and Polyfluoroalkyl Ketones. J Am Chem Soc 139:9053-9065|
|Kang, Taek; White, Kolby L; Mann, Tyler J et al. (2017) Enantioselective Total Synthesis of (-)-Deoxoapodine. Angew Chem Int Ed Engl 56:13857-13860|
|Shen, Xiao; Nguyen, Thach T; Koh, Ming Joo et al. (2017) Kinetically E-selective macrocyclic ring-closing metathesis. Nature 541:380-385|
|Koh, Ming Joo; Nguyen, Thach T; Lam, Jonathan K et al. (2017) Molybdenum chloride catalysts for Z-selective olefin metathesis reactions. Nature 542:80-85|
|Nguyen, Thach T; Koh, Ming Joo; Mann, Tyler J et al. (2017) Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis. Nature 552:347-354|
|van der Mei, Farid W; Miyamoto, Hiroshi; Silverio, Daniel L et al. (2016) Lewis Acid Catalyzed Borotropic Shifts in the Design of Diastereo- and Enantioselective ?-Additions of Allylboron Moieties to Aldimines. Angew Chem Int Ed Engl 55:4701-6|
|Yu, Elsie C; Johnson, Brett M; Townsend, Erik M et al. (2016) Synthesis of Linear (Z)-?,?-Unsaturated Esters by Catalytic Cross-Metathesis. The Influence of Acetonitrile. Angew Chem Int Ed Engl 55:13210-13214|
|Koh, Ming Joo; Nguyen, Thach T; Zhang, Hanmo et al. (2016) Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis. Nature 531:459-65|
|Nguyen, Thach T; Koh, Ming Joo; Shen, Xiao et al. (2016) Kinetically controlled E-selective catalytic olefin metathesis. Science 352:569-75|
|Yu, Miao; Schrock, Richard R; Hoveyda, Amir H (2015) Catalyst-controlled stereoselective olefin metathesis as a principal strategy in multistep synthesis design: a concise route to (+)-neopeltolide. Angew Chem Int Ed Engl 54:215-20|
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