The exploration of adaptation has been a keystone of evolutionary biology research since Darwin published Origin of Species. Despite this long history of investigation, the genetic basis of adaptation has only recently been studied in a comprehensive manner, primarily because until recently, the necessary genetic and genomic technologies were unavailable. One signature of adaptation in species with high migration rates is genetic differentiation between populations of the same species. In such cases, local selection in different environments is strong enough to overcome the homogenizing force of gene flow. The proposed work seeks to explore the genomics of adaptation along latitudinal clines in the genetic model system, Drosophila melanogaster. The work will use microarray analysis, DNA sequencing, and genetics, to describe variation in genes (and the associated phenotypes) influenced by spatially varying selection in D. melanogaster.

Public Health Relevance

The goal of this project is to use genomic technologies, population genetic approaches, and genetic analysis to understand variation in the Drosophila genome affecting phenotypes related to gametogenesis, meiosis and DNA repair. These approaches could eventually be used in human populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM084056-04
Application #
8257528
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Eckstrand, Irene A
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2012
Total Cost
$298,619
Indirect Cost
$102,599
Name
University of California Davis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
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