Mouse Models of Down Syndrome - Phenotypic Mapping

Epstein, Charles J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Project (R01)
• Project #: 5R01HD031498-02
• Application #: 2204051
• Study Section: Human Embryology and Development Subcommittee 1 (HED)
• Project Start: 1995-03-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of California San Francisco
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Shukkur, Ebrahim Abdul; Shimohata, Atsushi; Akagi, Takumi et al. (2006) Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet 15:2752-62

Antonarakis, Stylianos E; Epstein, Charles J (2006) The challenge of Down syndrome. Trends Mol Med 12:473-9

Villar, Angela J; Belichenko, Pavel V; Gillespie, Anne Marie et al. (2005) Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16:79-90

Dauphinot, L; Lyle, R; Rivals, I et al. (2005) The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome. Hum Mol Genet 14:373-84

Villar, A J; Kim, J; De Blank, P et al. (2005) Effects of genetic background on cardiovascular anomalies in the Ts16 mouse. Dev Dyn 232:131-9

Kleschevnikov, Alexander M; Belichenko, Pavel V; Villar, Angela J et al. (2004) Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24:8153-60

Olson, L E; Roper, R J; Baxter, L L et al. (2004) Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230:581-9

Amano, Kenji; Sago, Haruhiko; Uchikawa, Chiharu et al. (2004) Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum Mol Genet 13:1333-40

Belichenko, Pavel V; Masliah, Eliezer; Kleschevnikov, Alexander M et al. (2004) Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol 480:281-98

Cataldo, Anne M; Petanceska, Suzana; Peterhoff, Corrinne M et al. (2003) App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23:6788-92