This application is aimed at investigating the role leptin plays in puberty. We will study the effects of leptin on the stimulation of reproductive function in prepubertal normal male and female mice. We will determine whether treatment of normal female mice with neutralizing antibodies to leptin delays puberty and blocks the initiation of reproduction. Reproductive hormone levels will be determined in experimental mice treated with lelptin to find out whether these changes correlate with leptin levels at puberty. Furthermore, we will generate transgenic lines of mice that overexpress leptin at different levels and in a tissue-specific fashion. This animal model for lepltin-induced puberty will allow us to correlate various levels of leptin in the circulation with reproductive indexes at reproductive maturation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD035142-03
Application #
6181933
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Grave, Gilman D
Project Start
1998-05-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
3
Fiscal Year
2000
Total Cost
$175,584
Indirect Cost
Name
University of California San Francisco
Department
Pathology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143