This project will use developmental patterns of early emotional functioning and communication to predict social, behavioral, and cognitive functioning in the second and third year of life. Contrasts between 100 typically developing infant siblings and 100 infant siblings of children with Autism Spectrum Disorder (ASD) - who are at risk for a range of disruptions of emotion, communication, and cognition - will illuminate these developmental processes from a developmental psychopathology perspective. In the first year of life, associations between temperamental (Lab-TAB) and communicative (face-to-face/still-face) assessments of positive and negative emotion, cerebral indices of approach motivation (EEG laterality), and the development of communicative intentionality (infant joint attention) will be determined. These constructs will be used to predict a set of developmental^ linked processes including dyadic relationship quality, parent rated behavioral difficulties and strengths, standardized measures of linguistic and cognitive functioning, and ASD- related symptomatology in the second and third year of life. Relationship quality is a central construct, encompassing security of attachment, parental warmth and control, and child cooperation and warmeth in a range of social situations. Relationship quality is expected to mediate pathways to all outcomes with the exception of ASD symptomatology. Children with high levels of ASD symptomatology are expected to show deficits in both early measures emotional communication and later measures of social, communicative, and cognitive functioning. ASD symptomatology is expected to be directly related to early emotional functioning. This proposal utilizes multi-method assessment of emotional functioning early in infancy to confront the task of predicting intentional communication and later indices of healthy interaction, and competent linguistic and cognitive functioning. The models tested will shed specific light on the prediction and prevention of health- related outcomes including behavior problems, poor relationship quality, and ASD symptomatology in an at- risk and typically developing sample. Examination of predictive associations in typically developing infants and infant siblings of children with ASD will shed light on pathways to healthy development, psychopathologic deviations from those pathways, and potential intervention strategies for infants at risk for developmental difficulties.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD047417-05
Application #
7816917
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Esposito, Layla E
Project Start
2006-08-01
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2012-05-31
Support Year
5
Fiscal Year
2010
Total Cost
$295,172
Indirect Cost
Name
University of Miami Coral Gables
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
625174149
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
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McDonald, Nicole M; Murphy, Haley G; Messinger, Daniel S (2017) Empathic responding in preschool-aged children with familial risk for autism. Autism Res 10:1621-1628
Gangi, Devon N; Usher, Lauren V; Messinger, Daniel S (2017) An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder. Infant Behav Dev 49:267-271
Gangi, Devon N; Messinger, Daniel S; Martin, Eden R et al. (2016) Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention. Autism Res 9:1142-1150
McDonald, Nicole M; Baker, Jason K; Messinger, Daniel S (2016) Oxytocin and parent-child interaction in the development of empathy among children at risk for autism. Dev Psychol 52:735-45
Lambert-Brown, Brittany L; McDonald, Nicole M; Mattson, Whitney I et al. (2015) Positive emotional engagement and autism risk. Dev Psychol 51:848-55
Gangi, Devon N; IbaƱez, Lisa V; Messinger, Daniel S (2014) Joint attention initiation with and without positive affect: risk group differences and associations with ASD symptoms. J Autism Dev Disord 44:1414-24
Esposito, Gianluca; Del Carmen Rostagno, Maria; Venuti, Paola et al. (2014) Brief Report: Atypical expression of distress during the separation phase of the strange situation procedure in infant siblings at high risk for ASD. J Autism Dev Disord 44:975-80
Zwaigenbaum, Lonnie; Young, Gregory S; Stone, Wendy L et al. (2014) Early head growth in infants at risk of autism: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1053-62
Franklin, Beau; Warlaumont, Anne S; Messinger, Daniel et al. (2014) Effects of Parental Interaction on Infant Vocalization Rate, Variability and Vocal Type. Lang Learn Dev 10:279-2996

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