r The current Standard of Care for the rehabilitation of severely burned children is to discharge the patient from the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised anld structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children,

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD049471-08
Application #
8437091
Study Section
Skeletal Muscle and Exercise Physiology Study Section (SMEP)
Program Officer
Maholmes, Valerie
Project Start
2006-08-01
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
8
Fiscal Year
2013
Total Cost
$258,369
Indirect Cost
$87,264
Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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Edionwe, Joel; Hess, Cameron; Fernandez-Rio, Javier et al. (2016) Effects of whole-body vibration exercise on bone mineral content and density in thermally injured children. Burns 42:605-13
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Reeves, Patrick T; Herndon, David N; Tanksley, Jessica D et al. (2016) FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL. Shock 45:367-74
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Fry, Christopher S; Porter, Craig; Sidossis, Labros S et al. (2016) Satellite cell activation and apoptosis in skeletal muscle from severely burned children. J Physiol 594:5223-36

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