The proposed research is a novel application of structural equation models to identify the complex pathways through which cardiovascular disease (CVD) risk factors develop from the prenatal period to young adulthood. This research will make a substantial contribution to the growing field of developmental origins of adult health and disease (DOHaD). The project uses data from an ongoing community-based study of a birth cohort from Cebu, Philippines The Cebu Longitudinal Health and Nutrition Survey (CLHNS) recruited women during pregnancy, and has followed the offspring from birth to young adulthood. This 23 year study provides an unparalleled range of health, nutrition, socioeconomic, and environment data from roughly 2,000 individuals. The project includes the laboratory analysis of stored plasma samples to determine levels of multiple CVD risk factors, including lipid profiles (high &low density lipoprotein cholesterol, triglycerides), markers of inflammation (C-reactive protein, pro-inflammatory cytokines) and markers of glucose/insulin homeostasis (HOMA insulin sensitivity and adiponectin). These markers, in addition to blood pressure, and anthropometric indicators of adiposity will be outcome variables for our statistical models. The centerpiece of the project is the development and estimation of structural equation models that represent the complex pathways through which pre- and postnatal nutrition and nutrition-related factors contribute to the development of CVD risk in young adulthood. Key features of these models are that they will allow for the estimation of (a) persistent direct and indirect effects of prenatal exposures, (b) interactions of pre and postnatal factors, and (c) the effects of postnatal growth trajectories, including age/stage-specific effects (e.g. infancy, childhood, adolescence). The proposed research will make important methodological as well as substantive contributions by using methods that have not heretofore been applied to the DOHaD paradigm and by exploring a wide range of interrelated CVD risk factors.

Public Health Relevance

The proposed research will make important methodological and substantive contributions to our understanding of the developmental origins of cardiovascular disease risk in a cohort of Filipino young adults followed from the prenatal period to adulthood.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD054501-05
Application #
8304388
Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Raiten, Daniel J
Project Start
2008-09-18
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$393,332
Indirect Cost
$77,453
Name
University of North Carolina Chapel Hill
Department
Nutrition
Type
Schools of Public Health
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zubair, Niha; Kuzawa, Chris W; Lee, Nanette R et al. (2014) Clustering and determinants of cardiometabolic risk factors among Filipino young adults. Asia Pac J Clin Nutr 23:148-58
Lee, James; Fried, Ruby; Thayer, Zaneta et al. (2014) Preterm delivery as a predictor of diurnal cortisol profiles in adulthood: evidence from Cebu, Philippines. Am J Hum Biol 26:598-602
Bollen, Kenneth A; Noble, Mark D; Adair, Linda S (2013) Are gestational age, birth weight, and birth length indicators of favorable fetal growth conditions? A structural equation analysis of Filipino infants. Stat Med 32:2950-61
Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O et al. (2013) New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 45:76-82
Kuzawa, Christopher W; Hallal, Pedro C; Adair, Linda et al. (2012) Birth weight, postnatal weight gain, and adult body composition in five low and middle income countries. Am J Hum Biol 24:5-13
Zubair, Niha; Kuzawa, Chris W; McDade, Thomas W et al. (2012) Cluster analysis reveals important determinants of cardiometabolic risk patterns in Filipino women. Asia Pac J Clin Nutr 21:271-81
Wu, Ying; McDade, Thomas W; Kuzawa, Christopher W et al. (2012) Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. Inflammation 35:574-83
Thayer, Zaneta M; Feranil, Alan B; Kuzawa, Christopher W (2012) Maternal cortisol disproportionately impacts fetal growth in male offspring: evidence from the Philippines. Am J Hum Biol 24:1-4
Norris, Shane A; Osmond, Clive; Gigante, Denise et al. (2012) Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts. Diabetes Care 35:72-9
Tallman, Paula Skye; Kuzawa, Christopher; Adair, Linda et al. (2012) Microbial exposures in infancy predict levels of the immunoregulatory cytokine interleukin-4 in filipino young adults. Am J Hum Biol 24:446-53

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