Poor biobehavioral self-regulation likely contributes to a number of unhealthy behaviors as individuals seek and consume substances that improve self-regulation at a neurobiological level. Poor self-regulation begins very early in the lifespan, at a time when food is the only accessible substance with biological properties that aid the individual's ability to self-regulate. Children with poor self-regulation may therefore be more likely to tantrum for food, overeat and become overweight. There have been no studies to date integrating knowledge of biobehavioral self-regulation with eating behavior, dietary intake and weight status in early childhood. The study team was awarded a Challenge Grant in 2009 to examine some of these associations in low-income 3- to 5-year-olds, and the preliminary results of this project already demonstrate robust associations between aberrant diurnal salivary cortisol patterns, food-related tantrums, and overweight, beginning at age 36 months. In this low-income population, 40 percent of the children are already overweight by age 36 months, and a significant increase in overweight prevalence seems to occur around age 24 months. This application, therefore, proposes to collect measures of salivary cortisol and alpha amylase, self-regulation, eating behavior, diet, and anthropometry from 250 low-income children longitudinally at ages 21, 27, and 33 months. The study will provide more in-depth measures of these constructs from a younger cohort than has ever previously been studied, and in the low-income demographic that is at very high risk for both poor biobehavioral self-regulation and obesity. Structural equation modeling will be used to examine these potential associations.
The aims are to examine, among low-income toddlers longitudinally: (1) the relative contributions of food-related self-regulation, non-food related self-regulation, and salivary cortisol and alpha amylase to preference for comfort foods, emotional eating behavior, and weight status, and to determine if these relationships differ across ages 21, 27, and 33 months;(2) relationships between biobehavioral markers of self-regulation at 21 months with changes in weight status between 21 and 33 months, mediated by preference for comfort foods and emotional eating;(3) trajectories of the development of behavioral self-regulation, and to determine if these trajectories are associated with differences in preference for comfort foods, emotional eating behavior, and weight status at 33 months, independent of physiological markers of self-regulation at baseline. The results of this study will have implications for understanding biobehavioral mechanisms of excessive weight gain in toddlerhood, and thereby potentially contribute to more effective, novel, targeted prevention approaches. The results will also improve the understanding of contributors to health disparities based on socioeconomic status and may also have broad implications for the prevention of a wide range of unhealthy behaviors associated with difficulties with biobehavioral self-regulation.

Public Health Relevance

Poor biobehavioral self-regulation is believed to contribute to a number of unhealthy behaviors, including overeating and the development of obesity. Improved understanding of the development of associations between biobehavioral self-regulation, eating behavior, and excessive weight gain beginning in the toddler years may hold promise for novel targets for obesity prevention. Given that obesity and struggles with biobehavioral self-regulation are both more common among low-income children, the work may also hold particular promise for addressing socioeconomic disparities in obesity prevalence. In addition, overeating in toddlerhood may provide an important and unprecedented model for the early development of biobehavioral self-regulation contributing to a range of unhealthy behaviors. The results could therefore be broadly applicable to more effective prevention of other unhealthy behaviors such as substance abuse.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD069179-01
Application #
8067527
Study Section
Special Emphasis Panel (ZRG1-BBBP-R (50))
Program Officer
Haverkos, Lynne
Project Start
2010-09-29
Project End
2015-06-30
Budget Start
2010-09-29
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$510,973
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lumeng, Julie C; Miller, Alison L; Appugliese, Danielle et al. (2018) Picky eating, pressuring feeding, and growth in toddlers. Appetite 123:299-305
Julian, Megan M; Rosenblum, Katherine L; Doom, Jenalee R et al. (2018) Oxytocin and parenting behavior among impoverished mothers with low vs. high early life stress. Arch Womens Ment Health 21:375-382
Song, Ju-Hyun; Miller, Alison L; Leung, Christy Y Y et al. (2018) Positive Parenting Moderates the Association between Temperament and Self-Regulation in Low-Income Toddlers. J Child Fam Stud 27:2354-2364
Lumeng, Julie C; Kaciroti, Niko; Retzloff, Lauren et al. (2017) Longitudinal associations between maternal feeding and overweight in low-income toddlers. Appetite 113:23-29
Miller, Alison L; Kaciroti, Niko; Sturza, Julie et al. (2017) Associations between stress biology indicators and overweight across toddlerhood. Psychoneuroendocrinology 79:98-106
Bauer, Katherine W; Haines, Jess; Miller, Alison L et al. (2017) Maternal restrictive feeding and eating in the absence of hunger among toddlers: a cohort study. Int J Behav Nutr Phys Act 14:172
Miller, Alison L; Rosenblum, Katherine L; Retzloff, Lauren B et al. (2016) Observed self-regulation is associated with weight in low-income toddlers. Appetite 105:705-12
Kasper, Nicole; Mandell, Cami; Ball, Sarah et al. (2016) The Healthy Meal Index: A tool for measuring the healthfulness of meals served to children. Appetite 103:54-63
Asta, Katharine; Miller, Alison L; Retzloff, Lauren et al. (2016) Eating in the Absence of Hunger and Weight Gain in Low-income Toddlers. Pediatrics 137:
Miller, Alison L; Lumeng, Julie C; LeBourgeois, Monique K (2015) Sleep patterns and obesity in childhood. Curr Opin Endocrinol Diabetes Obes 22:41-7

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