Statistical methods for analyzing high-throughput genotype data Rapid technological progress makes high-throughput genotyping of thousands of SNPs feasible in large epidemiologic studies. Technologies to sequence an entire human genome for affordable cost is expected in near future. New statistical methods that are able to manage and analyze this sort of large scale data have not progressed as rapidly, however. This renewal application requests support to continue statistical methodological developments in analyzing large scale genetic data sets. We propose to use a variety of large genetic data sets to test the newly developed statistical methods.
Specific aims i nclude 1) Develop statistical methods to detect rare genetic variants using whole genome scan or sequence data. We will develop a variety of designs to cluster rare risk haplotypes and then perform association analysis with these risk haplotypes as a group in candidate gene association studies. 2) Develop statistical association methods that control for population stratification using whole genome data. 3) Develop statistical methods to jointly model admixture mapping and association in order to search for potential causal variants contributing to the admixture mapping signals. 4) Develop corresponding software that will be made available in the S.A.G.E. (Statistical Analysis for Genetic Epidemiology) program package which will be widely distributed. We will collaborate with laboratory-based investigators to obtain appropriate data sets, including our hypertension and obesity related data, and apply new analytic methods to this crucial practical problem in genetic epidemiology.

Public Health Relevance

This is a continuation of research with the aims of developing novel statistical methods for detecting genetic variants underlying common diseases. We will develop the statistical methods of detecting rare variants, controlling population stratification, performing the joint analysis of admixture mapping and association and developing new software.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
2R01HG003054-05A1
Application #
7784727
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Brooks, Lisa
Project Start
2005-03-15
Project End
2013-04-30
Budget Start
2010-05-13
Budget End
2011-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$392,500
Indirect Cost
Name
Case Western Reserve University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Wang, Ya-Juan; Tayo, Bamidele O; Bandyopadhyay, Anupam et al. (2014) The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function. PLoS Genet 10:e1004641

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