The present proposal will investigate the effects of antihypertensive drugs on sensory function, motor ability, learning and memory in baboons both when they are normotensive, and after an experimental hypertensive state has been induced. Clinical case reports of adverse behavioral side-effects of antihypertensive compounds have been frequent, leading many patients to discontinue medication. Unfortunately, both human and animal investigations have been equivocal as to the behavioral performance and sensory effects of frequently used drugs such as beta-blockers, and centrally acting antihypertensive compounds. Detailed information is lacking on the behavioral and sensory effects of diuretics, and on the newer antihypertensive compounds such as angiotensin-converting-enzyme inhibitors and calcium-channel blockers. The proposed project will use two baboon models of hypertension, a deoxycorticosterone acetate (DOCA)-salt model and a Goldblatt (two-kidney, one-clamp) model, to simulate low renin and high renin states of hypertension, respectively. The effects of five different classes of antihypertensive compounds will be examined in these two models with continuous blood pressure monitoring via implanted arterial catheters. Detailed assessments of both behavioral and central nervous system effects of these antihypertensive agents will be provided by having animals perform tasks designed to assess sensory and motor function as well as specific aspects of conditional learning and memory.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034034-03
Application #
3346571
Study Section
Biopsychology Study Section (BPO)
Project Start
1986-04-01
Project End
1989-11-30
Budget Start
1988-04-01
Budget End
1989-11-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Turkkan, J S; Hienz, R D; Allen, R P et al. (1992) Beta-blocker effects on 24-h activity in normotensive and renovascular hypertensive baboons. Pharmacol Biochem Behav 42:465-71
Turkkan, J S; Hienz, R D (1992) Behavioral performance effects of verapamil in normotensive and renovascular hypertensive baboons. Integr Physiol Behav Sci 27:142-50
Turkkan, J S; Hienz, R D (1992) Performance of baboons under a repeated acquisition procedure during chronic oral exposure to atenolol and propranolol. Psychopharmacology (Berl) 109:484-8
Turkkan, J S; Allen, R P; Hienz, R D (1992) Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons. Pharmacol Biochem Behav 41:567-72
Turkkan, J S; Hienz, R D (1991) Behavioral effects of chronic, orally administered diuretic and verapamil in baboons. Pharmacol Biochem Behav 38:55-62
Turkkan, J S (1990) New methodology for measuring blood pressure in awake baboons with use of behavioral training techniques. J Med Primatol 19:455-66
Turkkan, J S; Hienz, R D (1989) Behavioral performance effects of nifedipine in normotensive baboons: single dosing. Pharmacol Biochem Behav 33:923-6
Brady, J V (1989) Neither a mentalist nor a reductionist be! Biofeedback Self Regul 14:185-93
Turkkan, J S; Hienz, R D (1989) Matching to sample, blood pressure and hormonal effects of chronic enalapril in baboons. Pharmacol Biochem Behav 34:685-90
Turkkan, J S (1988) Behavioral performance effects of antihypertensive drugs: human and animal studies. Neurosci Biobehav Rev 12:111-22