Newborns spend a large portion of their time asleep. During the first postnatal month--a time when numerous cardiorespiratory changes are occurring--lambs spend about 45% of their time in quiet sleep and about 10% of their time in active sleep. Very little is known about the influence of sleep on baseline cardiorespiratory regulation or of the reflex cardiorespiratory response(s) to perturbation in young animals. I propose to do experiments to investigate: 1) the effects of sleep on baseline cardiorespiratory regulation during postnatal development, 2) the effects of sleep on cardiorespiratory regulation following sino-aortic denervation during postnatal development, 3) the effects of sleep on the cardiorespiratory response to perturbation (i.e., upper airway obstruction) before and after sino-aortic denervation during postnatal development, 4) the effects of environmental temperature on baseline cardiorespiratory regulation and the response to perturbation in sleep before and after sino-aortic denervation, and 5) the effects of sleep fragmentation on baseline cardiorespiratory regulation and the response to perturbation in sleep before and after sino-aortic denervation. The proposed studies will provide important information about the cardiovascular and the respiratory systems during sleep and may provide insight into the pathophysiology of some events such as intracranial hemorrhage and sudden infant death.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034377-05
Application #
3347234
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1986-07-01
Project End
1991-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Fewell, J E; Ricciuti, F; Kondo, C S et al. (1991) Fever in young lambs: temperature, metabolic and cardiorespiratory responses to a small dose of bacterial pyrogen. J Dev Physiol 15:229-35
Fewell, J E; Taylor, B J; Kondo, C S et al. (1990) Influence of carotid denervation on the arousal and cardiopulmonary responses to upper airway obstruction in lambs. Pediatr Res 28:374-8
Fewell, J E; Kondo, C S; Dascalu, V (1990) Influence of sleep on the cardiovascular and metabolic responses to a decrease in ambient temperature in lambs. J Dev Physiol 13:223-30
Fewell, J E; Baker, S B (1989) Arousal and cardiopulmonary responses to hyperoxic hypercapnia in lambs. J Dev Physiol 12:21-6
Fewell, J E; Kondo, C S; Dascalu, V et al. (1989) Influence of carotid denervation on the arousal and cardiopulmonary response to rapidly developing hypoxemia in lambs. Pediatr Res 25:473-7
Fewell, J E; Konduri, G G (1989) Influence of repeated exposure to rapidly developing hypoxaemia on the arousal and cardiopulmonary response to rapidly developing hypoxaemia in lambs. J Dev Physiol 11:77-82
Fewell, J E; Williams, B J; Szabo, J S et al. (1988) Influence of repeated upper airway obstruction on the arousal and cardiopulmonary response to upper airway obstruction in lambs. Pediatr Res 23:191-5
Fewell, J E; Konduri, G G (1988) Repeated exposure to rapidly developing hypoxemia influences the interaction between oxygen and carbon dioxide in initiating arousal from sleep in lambs. Pediatr Res 24:28-33
Fewell, J E; Baker, S B (1987) Arousal from sleep during rapidly developing hypoxemia in lambs. Pediatr Res 22:471-7
Fewell, J E (1987) The effect of short-term sleep fragmentation produced by intense auditory stimuli on the arousal response to upper airway obstruction in lambs. J Dev Physiol 9:409-17