This application represents a revised competing renewal application of ROl H141993-06 entitled """"""""Polyunsaturated Fats and Primary Cardiac Arrest."""""""" During the prior project periods, we demonstrated that 1) modest dietary intake of long-chain n-3 polyunsaturated fatty acids (PUFAs) from seafood (20:5n-3, EPA and 22:6n-3, DHA), measured directly through a questionnaire and indirectly through red-cell membrane fatty acid composition, was associated with a lower risk of primary cardiac arrest (PCA); and, 2) red-cell membrane levels of trans-isomers of linoleic acid (trans-18:2) but not trans-isomers of oleic acid (trans-18:1) were associated with an increased risk of PCA. We now propose to extend our population-based case-control study to determine whether modest dietary intake of the intermediate-chain n-3 PUFA (18:3n-3, ALA), assessed using red-cell membrane fatty acid composition, is associated with a lower risk of PCA, particularly in the setting of low intake of EPA/DHA. We will continue to identify cases of PCA who are attended by paramedics in King County, Washington (through January 2005). Demographically-similar controls will continue to be identified from the same community using random-digit-dialing. Blood specimens from newly identified cases (collected by paramedics in the field) and controls will be analyzed for red-cell membrane levels of ALA and other fatty acids. Spouses of subjects will be interviewed to assess other risk factors, usual saturated fat intake, and recent changes in diet. Analyses will focus on the relation between ALA and risk of PCA in the context of a diet low in EPA/DHA, after adjusting for red-cell membrane linoleic acid and trans-fatty acid levels and other risk factors. To determine whether the association between ALA levels and risk of PCA may result from uncontrolled confounding from other nutrients, we will conduct a dietary intake substudy on newly identified control subjects and assess the relation of red-cell membrane ALA levels with other nutrients, measured using a food frequency questionnaire. The proposed research provides a unique opportunity to examine more fully the role of dietary intake of n-3 PUFAs, particularly ALA, in efforts to reduce PCA, a major component of coronary heart disease mortality in the community.
| Mujahid, Mahasin S; James, Sherman A; Kaplan, George A et al. (2017) Socioeconomic position, John Henryism, and incidence of acute myocardial infarction in Finnish men. Soc Sci Med 173:54-62 |
| Lemaitre, Rozenn N; King, Irena B; Rice, Kenneth et al. (2014) Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. Prostaglandins Leukot Essent Fatty Acids 91:149-53 |
| Grove, Megan L; Yu, Bing; Cochran, Barbara J et al. (2013) Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One 8:e68095 |
| Wicks, April F; Lumley, Thomas; Lemaitre, Rozenn N et al. (2012) Major life events as potential triggers of sudden cardiac arrest. Epidemiology 23:482-5 |
| Lemaitre, Rozenn N; King, Irena B; Sotoodehnia, Nona et al. (2010) Endogenous red blood cell membrane fatty acids and sudden cardiac arrest. Metabolism 59:1029-34 |
| Lemaitre, Rozenn N; King, Irena B; Sotoodehnia, Nona et al. (2009) Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest. Metabolism 58:534-40 |
| Sotoodehnia, Nona; Li, Guo; Johnson, Catherine O et al. (2009) Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Heart Rhythm 6:1306-14 |
| Sotoodehnia, Nona; Siscovick, David S; Vatta, Matteo et al. (2006) Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation 113:1842-8 |
| Longstreth Jr, W T; Schellenberg, G D; Fahrenbruch, C E et al. (2003) Apolipoprotein E genotypes and outcome from out of hospital cardiac arrest. J Neurol Neurosurg Psychiatry 74:1441-3 |
| Reiner, Alexander P; Rosendaal, Frits R; Reitsma, Pieter H et al. (2002) Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons. Am J Cardiol 90:66-8 |
Showing the most recent 10 out of 19 publications
