Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL048114-02S1
Application #
879113
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Temple University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Sakolsky, D J; Ashby, B (2001) Patterns of cyclic AMP formation by coexpressed D1 and D2L dopamine receptors in HEK 293 cells. Receptors Channels 7:479-89
Bastepe, M; Ashby, B (1999) Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor. Br J Pharmacol 126:365-71
Daniel, J L; Dangelmaier, C; Jin, J et al. (1998) Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 273:2024-9
Paul, B Z; Ashby, B; Sheth, S B (1998) Distribution of prostaglandin IP and EP receptor subtypes and isoforms in platelets and human umbilical artery smooth muscle cells. Br J Haematol 102:1204-11
Ashby, B (1998) Co-expression of prostaglandin receptors with opposite effects: a model for homeostatic control of autocrine and paracrine signaling. Biochem Pharmacol 55:239-46
Ortiz-Vega, S; Ashby, B (1997) Human prostacyclin receptor: cloning and co-expression with EP3 prostaglandin receptor. Adv Exp Med Biol 433:235-8
Jin, J; Mao, G F; Ashby, B (1997) Constitutive activity of human prostaglandin E receptor EP3 isoforms. Br J Pharmacol 121:317-23
Bastepe, M; Ashby, B (1997) The long cytoplasmic carboxyl terminus of the prostaglandin E2 receptor EP4 subtype is essential for agonist-induced desensitization. Mol Pharmacol 51:343-9
Mao, G F; Jin, J G; Bastepe, M et al. (1996) Prostaglandin E2 both stimulates and inhibits adenyl cyclase on platelets: comparison of effects on cloned EP4 and EP3 prostaglandin receptor subtypes. Prostaglandins 52:175-85
Kunapuli, S P; Fen Mao, G; Bastepe, M et al. (1994) Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells. Biochem J 298 ( Pt 2):263-7