Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049810-03
Application #
2225858
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1994-04-15
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kurahashi, Kiyoyasu; Sawa, Teiji; Ota, Maria et al. (2009) Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 296:L198-209
Ernst, E J; Hashimoto, S; Guglielmo, J et al. (1999) Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. Antimicrob Agents Chemother 43:2389-94
Miyazaki, H; Broaddus, V C; Wiener-Kronish, J P et al. (1999) The effects of two antiinflammatory pretreatments on bacterial-induced lung injury. Anesthesiology 90:1650-62
Kurahashi, K; Kajikawa, O; Sawa, T et al. (1999) Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest 104:743-50
Sawa, T; Kurahashi, K; Ohara, M et al. (1998) Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob Agents Chemother 42:3269-75
Sawa, T; Ohara, M; Kurahashi, K et al. (1998) In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infect Immun 66:3242-9
Pittet, J F; Kudoh, I; Wiener-Kronish, J P (1998) Endothelial exposure to Pseudomonas aeruginosa proteases increases the vulnerability of the alveolar epithelium to a second injury. Am J Respir Cell Mol Biol 18:129-35
Ohara, M; Sawa, T; Kurahashi, K et al. (1998) Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production. Anesthesiology 88:1014-22
McElroy, M C; Wiener-Kronish, J P; Miyazaki, H et al. (1997) Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats. Am J Physiol 272:L631-8
Finck-Barbancon, V; Goranson, J; Zhu, L et al. (1997) ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. Mol Microbiol 25:547-57

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