Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL049915-02S1
Application #
837169
Study Section
Experimental Immunology Study Section (EI)
Project Start
1994-06-01
Project End
1996-03-31
Budget Start
1994-06-01
Budget End
1995-03-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Sykes, M (2015) Immune tolerance in recipients of combined haploidentical bone marrow and kidney transplantation. Bone Marrow Transplant 50 Suppl 2:S82-6
Haspot, F; Li, H W; Lucas, C L et al. (2014) Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. Am J Transplant 14:49-58
Strober, Samuel; Spitzer, Thomas R; Lowsky, Robert et al. (2011) Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. Semin Immunol 23:273-81
Lucas, Carrie L; Workman, Creg J; Beyaz, Semir et al. (2011) LAG-3, TGF-?, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood 117:5532-40
Hermanrud, Christina E; Lucas, Carrie L; Sykes, Megan et al. (2011) Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris. Protein Expr Purif 76:115-20
Levesque, V; Bardwell, P D; Shimizu, I et al. (2011) B-cell-dependent memory T cells impede nonmyeloablative mixed chimerism induction in presensitized mice. Am J Transplant 11:2322-31
Mollov, J L; Lucas, C L; Haspot, F et al. (2010) Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance. Am J Transplant 10:518-526
Nikolic, Boris; Onoe, Takashi; Takeuchi, Yasuo et al. (2010) Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice. Transplantation 89:23-32
Fehr, Thomas; Lucas, Carrie L; Kurtz, Josef et al. (2010) A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood 115:1280-7
Sykes, Megan (2009) Mechanisms of transplantation tolerance in animals and humans. Transplantation 87:S67-9

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