In addition to elevated blood pressure, hypertension is characterized by neuroimmune and cell adhesion molecule activation, which are predictive of morbidity and mortality-outcomes. Pharmacological treatment for hypertension successfully reduces blood pressure, but has limited effectiveness for reducing accompanying pro-atherogenic inflammation. Exercise plus dietary interventions have been shown to reduce inflammation, but few if any studies have examined their effects on inflammation in hypertension. Our studies to date have extended the current literature on inflammation in human Hypertension showing that in addition to endothelial activation, hypertensive subjects display increased expression of cellular adhesion molecules on circulating leukocytes, and increased proinflammatory cytokine and leukocyte reactivity to stressors. These effects support an adverse circulating environment of increased leukocyte adhesion and migration. The primary aim of this revised competing renewal of HL57265 is to determine the effects of a 12-week exercise intervention and a 12-week exercise plus diet intervention on inflammation and cell adhesion in 150 patients with hypertension. Prior to and following the interventions, we will assess resting and stress-induced (speech stressor and acute treadmill testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1 and sE-selectin, leukocyte CDlla and CDlib expression, leukocyte activation, and peripheral blood mononuclear cell chemotaxis. Changes in cardiovascular fitness, weight, neuroendocrineactivation (catecholamine and cortisol levels), and insulin sensitivity will be examined as possible mechanisms for the anticipated reductions in inflammationand cell adhesion.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL057265-12
Application #
7776872
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Czajkowski, Susan
Project Start
1997-08-01
Project End
2012-01-31
Budget Start
2010-02-01
Budget End
2012-01-31
Support Year
12
Fiscal Year
2010
Total Cost
$448,595
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
von Känel, Roland (2015) ACUTE MENTAL STRESS AND HEMOSTASIS: WHEN PHYSIOLOGY BECOMES VASCULAR HARM. Thromb Res 135:S52-S55
von Känel, Roland (2015) Acute mental stress and hemostasis: When physiology becomes vascular harm. Thromb Res 135 Suppl 1:S52-5
Redwine, Laura S; Hong, Suzi; Rutledge, Thomas et al. (2014) Leukocyte ß-adrenergic receptor sensitivity and depression severity in patients with heart failure. Psychosom Med 76:726-31
Sadja, Julie; Mills, Paul J (2013) Effects of yoga interventions on fatigue in cancer patients and survivors: a systematic review of randomized controlled trials. Explore (NY) 9:232-43
Jiménez, Jessica A; Redwine, Laura L; Rutledge, Thomas R et al. (2012) Depression ratings and antidepressant use among outpatient heart failure patients: implications for the screening and treatment of depression. Int J Psychiatry Med 44:315-34
Ziegler, Michael G; Milic, Milos (2012) New therapies for postural hypotension. Hypertension 59:548-9
Sadja, Julie; Tomfohr, Lianne; Jiménez, Jessica A et al. (2012) Higher physical fatigue predicts adherence to a 12-week exercise intervention in women with elevated blood pressure. Health Psychol 31:156-63
Wilson, Kathleen L; Tomfohr, Lianne; Edwards, Kate et al. (2012) Effects of Aerobic Fitness and Adiposity on Coagulation Biomarkers in Men vs. Women with Elevated Blood Pressure. Eur J Cardiovasc Med 2:122-128
Shoucri, Bassem M; Edwards, Kate M; Schmid-Schönbein, Geert W et al. (2011) Plasma-stimulated pseudopod formation is increased in patients with elevated blood pressure. Hypertens Res 34:787-9
Edwards, K M; Wilson, K L; Sadja, J et al. (2011) Effects on blood pressure and autonomic nervous system function of a 12-week exercise or exercise plus DASH-diet intervention in individuals with elevated blood pressure. Acta Physiol (Oxf) 203:343-50

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