A relation of lowered cholesterol to increased aggressive behaviors (including suicide) and impaired cognition has been variably demonstrated and remains to be established or excluded with confidence. HMG-CoA reductase inhibitors (""""""""statins"""""""") are the most widely used agents and their effects are of special interest. Purpose: To examine the effect of statins on aggressive responding, cognition, and serotonin in individuals with moderate LDL and no identified cardiovascular disease (CVD). Hypothesis: Statin therapy will increase aggressive responding on the PSAP (Point Subtraction Aggression paradigm, a standardized aggression measure that correlates with both violent behavior and serotonin); will reduce measures of cognition (including psychomotor speed and attention); and will change serotonin (gauged by whole blood serotonin), which may be a mediator of effects on behavior and perhaps cognition. Secondarily, it is hypothesized that simvastatin (lipophilic) will exert more potent effects on cognition (and perhaps aggression) than pravastatin (hydrophilic); that serotonin (5HT) changes will related to changes in aggressive responding and perhaps cognition; and that a """"""""susceptible subset"""""""" may be defined by baseline characteristics including biochemistry, mood, personality, and extremes of cardiovascular reactivity.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Behavioral Medicine Study Section (BEM)
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Jobe, Jared B
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
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Golomb, Beatrice A; Dimsdale, Joel E; Koslik, Hayley J et al. (2015) Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial. PLoS One 10:e0124451
Golomb, Beatrice Alexandra; Bui, Alexis K (2015) A Fat to Forget: Trans Fat Consumption and Memory. PLoS One 10:e0128129
Golomb, Beatrice A; Evans, Marcella A; White, Halbert L et al. (2012) Trans fat consumption and aggression. PLoS One 7:e32175
Golomb, Beatrice A; Chan, Virginia T; Evans, Marcella A et al. (2012) The older the better: are elderly study participants more non-representative? A cross-sectional analysis of clinical trial and observational study samples. BMJ Open 2:
Golomb, Beatrice A; Evans, Marcella A; Dimsdale, Joel E et al. (2012) Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial. Arch Intern Med 172:1180-2
Golomb, Beatrice A; Koperski, Sabrina; White, Halbert L (2012) Association between more frequent chocolate consumption and lower body mass index. Arch Intern Med 172:519-21
Rose, Natalie; Koperski, Sabrina; Golomb, Beatrice A (2010) Mood food: chocolate and depressive symptoms in a cross-sectional analysis. Arch Intern Med 170:699-703
Golomb, Beatrice A; Yaghmai, Reza; Renvall, Marian J et al. (2010) Electronic medical records and upper extremity symptoms: pain with the gain? Arch Intern Med 170:655-7
Cham, Stephanie; Evans, Marcella A; Denenberg, Julie O et al. (2010) Statin-associated muscle-related adverse effects: a case series of 354 patients. Pharmacotherapy 30:541-53
Golomb, Beatrice A; Evans, Marcella A (2008) Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs 8:373-418

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