We have recently developed an isotropic angular projection acquisition technique (VIPR) that allows for large angular undersampling factors for situations in which the contrast signals of interest dominate. The technique is especially promising for phase contrast (PC) imaging where the excellent background suppression eliminates non-vascular streak artifacts. The high speed of VIPR can be used to produce several PC implementations 4-25 times faster than conventional PC when large imaging volumes are used and with scan times and isotropic spatial resolution comparable to 3D Time-of Flight (TOF). We wish to test the hypothesis that 3D VIPR-PC can provide anatomical information equivalent to and sometimes better than 3D TOF while also providing the opportunity for retrospective measurement of flow in all major vessels in the 3D volume with accuracy comparable to multiple 2D PC scans. We propose three implementations of VIPR-PC: (1) A Basic VIPR-PC version that will use a single velocity encoding (VENC) and provide significantly higher spatial resolution than conventional 3DPC. We will test its ability to measure average flow retrospectively for all vessels in the imaging volume. It will also be compared to 3D TOF for the purpose of providing anatomical information. (2) A velocity resolved non-gated method for providing velocity and speed distributions within voxels and for generation of angiographic images which have higher SNR than obtainable with a single VENC, and (3) A cardiac phase-resolved (CINE) version to provide the opportunity for retrospective determination of flow waveforms within all vessels in a large FOV without the need to acquire separate 2D scans for each vessel. We propose to develop and optimize the proposed methods and to test their feasibility using simulations, phantoms, and a series of studies using volunteers and patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL072260-03
Application #
6881540
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Buxton, Denis B
Project Start
2003-05-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$349,735
Indirect Cost
Name
University of Wisconsin Madison
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Johnson, Kevin M (2017) Hybrid radial-cones trajectory for accelerated MRI. Magn Reson Med 77:1068-1081
Rivera-Rivera, L A; Johnson, K M; Turski, P A et al. (2017) Pressure Mapping and Hemodynamic Assessment of Intracranial Dural Sinuses and Dural Arteriovenous Fistulas with 4D Flow MRI. AJNR Am J Neuroradiol :
Roldán-Alzate, Alejandro; Francois, Christopher J; Wieben, Oliver et al. (2016) Emerging Applications of Abdominal 4D Flow MRI. AJR Am J Roentgenol 207:58-66
Rivera-Rivera, Leonardo A; Turski, Patrick; Johnson, Kevin M et al. (2016) 4D flow MRI for intracranial hemodynamics assessment in Alzheimer's disease. J Cereb Blood Flow Metab 36:1718-1730
Roldán-Alzate, Alejandro; Frydrychowicz, Alex; Said, Adnan et al. (2015) Impaired regulation of portal venous flow in response to a meal challenge as quantified by 4D flow MRI. J Magn Reson Imaging 42:1009-17
Jeong, Daniel; Anagnostopoulos, Petros V; Roldan-Alzate, Alejandro et al. (2015) Ventricular kinetic energy may provide a novel noninvasive way to assess ventricular performance in patients with repaired tetralogy of Fallot. J Thorac Cardiovasc Surg 149:1339-47
Schrauben, Eric; Wåhlin, Anders; Ambarki, Khalid et al. (2015) Fast 4D flow MRI intracranial segmentation and quantification in tortuous arteries. J Magn Reson Imaging 42:1458-64
Barker, Alex J; Roldán-Alzate, Alejandro; Entezari, Pegah et al. (2015) Four-dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: results from two institutions. Magn Reson Med 73:1904-13
Schrauben, Eric M; Anderson, Ashley G; Johnson, Kevin M et al. (2015) Respiratory-induced venous blood flow effects using flexible retrospective double-gating. J Magn Reson Imaging 42:211-6

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