All present day prosthetic heart valves suffer from complications. Mechanical heart valves (HVs) require life-long anti-coagulation therapy, while bioprosthetic heart valves based on fixed tissue are plagued with durability, immunogenic and calcification issues. Polymeric heart valves promise to combine the best of the mechanical valves and the best of the bioprosthetic heart valves. Our lab has developed a novel biomaterial, BioPoly, made of engineering polymers that are, at a molecular level, interlocked with hyaluronan (HA, a naturally occurring polysaccharide) to make highly hydrophilic hemocompatible polymer leaflets with the durability of engineered synthetic polymers. Preliminary work has shown that BioPoly leaflets have remarkably reduced thrombogenic potential relative to plain polymer leaflets. Further, we have already demonstrated the feasibility of manufacturing BioPoly leaflets and assembling them into an implantable trileaflet valve. The present R01 study aims to gauge the efficacy of BioPoly as a potential alternative to current heart valve technology by fine tuning material composition and processing to meet the durability and antithrombogenic requirements for heart valve leaflets. Our central hypothesis is: BioPoly HVs offer a viable solution to the drawbacks of both bioprosthetic and mechanical HVs. This is tested in three aims.
Aim 1 quantifies heart valve hemodynamic performance and the durability/fatigue characteristics of BioPoly heart valves.
Aim 2 focuses on elucidating the effects of leaflet composition and processing on hemocompatibility.
Aim 3 focuses on understanding the in vivo hemocompatibility and calcification properties of BioPoly HV. This proposal is led by Dr. Lakshmi Prasad Dasi, who is a well-trained young investigator with expertise in heart valve engineering and cardiovascular biomechanics. Co-investigators are Dr. James, who is an established polymer materials scientist, and the inventor of BioPoly. She has successfully translated this material in orthopedic applications (currently commercially available in Europe); Dr. Popat whose expertise lies in bio-compatibility and surface nano-engineering; and Dr. Orton an experienced Veterinary cardiothoracic surgeon. If the proposed work demonstrates that BioPoly leaflet HVs are antithrombogenic, elicit excellent hemodynamics, are durable, and demonstrate resistance to in vivo calcification, this R01 grant may lead to breakthrough technology for polymeric HVs that require little or no anticoagulation, can be delivered minimally invasively and are durable enough to last a lifetime.

Public Health Relevance

The objective of this project is to develop an advanced polymeric heart valve that is engineered for maximum blood compatibility through the use of cross-linked hyaluronan, which is present in all tissues. State-of-the-art manufacturing, experimental studies in the areas of mechanics and materials sciences are utilized to construct this novel heart valve. The proposed innovative approach combines these methods and techniques to optimize a highly innovative concept in a unique interdisciplinary effort to produce durable and highly functional polymeric heart valves. This novel technology will lead to a dramatic improvement in heart valve technology.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Bioengineering, Technology and Surgical Sciences Study Section (BTSS)
Program Officer
Evans, Frank
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Colorado State University-Fort Collins
Engineering (All Types)
Biomed Engr/Col Engr/Engr Sta
Fort Collins
United States
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Simon-Walker, Rachael; Cavicchia, John; Prawel, David A et al. (2017) Hemocompatibility of hyaluronan enhanced linear low density polyethylene for blood contacting applications. J Biomed Mater Res B Appl Biomater :
Hatoum, Hoda; Moore, Brandon L; Maureira, Pablo et al. (2017) Aortic sinus flow stasis likely in valve-in-valve transcatheter aortic valve implantation. J Thorac Cardiovasc Surg 154:32-43.e1
Dasi, Lakshmi P; Hatoum, Hoda; Kheradvar, Arash et al. (2017) On the Mechanics of Transcatheter Aortic Valve Replacement. Ann Biomed Eng 45:310-331
Yousefi, Atieh; Bark, David L; Dasi, Lakshmi P (2017) Effect of Arched Leaflets and Stent Profile on the Hemodynamics of Tri-Leaflet Flexible Polymeric Heart Valves. Ann Biomed Eng 45:464-475
Bark Jr, David L; Vahabi, Hamed; Bui, Hieu et al. (2017) Hemodynamic Performance and Thrombogenic Properties of a Superhydrophobic Bileaflet Mechanical Heart Valve. Ann Biomed Eng 45:452-463
Bark Jr, David L; Yousefi, Atieh; Forleo, Marcio et al. (2016) Reynolds shear stress for textile prosthetic heart valves in relation to fabric design. J Mech Behav Biomed Mater 60:280-287
Bark Jr, David L; Dasi, Lakshmi P (2016) The Impact of Fluid Inertia on In Vivo Estimation of Mitral Valve Leaflet Constitutive Properties and Mechanics. Ann Biomed Eng 44:1425-35
Moore, Brandon L; Dasi, Lakshmi Prasad (2015) Coronary Flow Impacts Aortic Leaflet Mechanics and Aortic Sinus Hemodynamics. Ann Biomed Eng 43:2231-41
Moore, Brandon; Dasi, Lakshmi Prasad (2014) SPATIO-TEMPORAL COMPLEXITY OF THE AORTIC SINUS VORTEX. Exp Fluids 55:1770
Morshed, Khandakar Niaz; Bark Jr, David; Forleo, Marcio et al. (2014) Theory to predict shear stress on cells in turbulent blood flow. PLoS One 9:e105357

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